Safety of new biologics (vedolizumab and ustekinumab) and small molecules (tofacitinib) during pregnancy: a review

JP Gisbert, M Chaparro - Drugs, 2020 - Springer
Two new biological drugs (vedolizumab and ustekinumab) and one small molecule
(tofacitinib) have been recently approved for the treatment of inflammatory bowel disease …

ECCO guidelines on the prevention, diagnosis, and management of infections in inflammatory bowel disease

T Kucharzik, P Ellul, T Greuter, JF Rahier… - Journal of Crohn's …, 2021 - academic.oup.com
The introduction and broad use of new immunosuppressive agents, including biologic
agents and JAK inhibitors, have revolutionised treatment of inflammatory bowel disease …

The use and impact of monoclonal antibody biologics during pregnancy

A Pham-Huy, KA Top, C Constantinescu, CH Seow… - Cmaj, 2021 - Can Med Assoc
• Increasingly, pregnant patients with inflammatory or autoimmune diseases use monoclonal
antibody biologics before conception, during pregnancy and while breastfeeding.• A minority …

Pregnancy outcomes in inflammatory bowel disease patients treated with vedolizumab, anti‐TNF or conventional therapy: results of the European CONCEIVE study

A Moens, CJ van der Woude… - Alimentary …, 2020 - Wiley Online Library
Background Women with inflammatory bowel diseases (IBD) often receive biologicals
during pregnancy to maintain disease remission. Data on outcome of vedolizumab‐exposed …

Safety of ustekinumab or vedolizumab in pregnant inflammatory bowel disease patients: a multicentre cohort study

P Wils, P Seksik, C Stefanescu… - Alimentary …, 2021 - Wiley Online Library
Background The prevalence of inflammatory bowel diseases (IBD) is high in women of
childbearing age. Achieving clinical remission from conception to delivery using current …

Infliximab, adalimumab and vedolizumab concentrations across pregnancy and vedolizumab concentrations in infants following intrauterine exposure

E Flanagan, PR Gibson, EK Wright… - Alimentary …, 2020 - Wiley Online Library
Background The impact of pregnancy on levels of biologic agents in patients with IBD is
undefined and time to elimination in vedolizumab‐exposed infants is unknown. Aims To …

IBD in pregnancy: recent advances, practical management

CP Selinger, C Nelson-Piercy, A Fraser, V Hall… - Frontline …, 2021 - fg.bmj.com
Inflammatory bowel disease (IBD) poses complex issues in pregnancy, but with high-quality
care excellent pregnancy outcomes are achievable. In this article, we review the current …

New drugs for the treatment of IBD during conception, pregnancy, and lactation

D Pugliese, G Privitera, JP Gisbert… - Digestive and Liver …, 2024 - Elsevier
The management of inflammatory bowel disease requires continuous medical therapy to
achieve and maintain disease control. Thus, women can be exposed to different drugs …

Vedolizumab clearance in neonates, susceptibility to infections and developmental milestones: a prospective multicentre population‐based cohort study

M Julsgaard, DC Baumgart… - Alimentary …, 2021 - Wiley Online Library
Background Little is known about the consequences of intrauterine exposure to, and the
post‐natal clearance of, vedolizumab. Aims To investigate the levels of vedolizumab in …

Vaccines in Children Exposed to Biological Agents In Utero and/or During Breastfeeding: Are They Effective and Safe?

JP Gisbert, M Chaparro - Journal of Crohn's and Colitis, 2023 - academic.oup.com
Background Biological agents cross the placenta, resulting in detectable blood levels in the
neonate. Neonatal vaccinations are essential to prevent serious infections. Aim To review …