Safety of new biologics (vedolizumab and ustekinumab) and small molecules (tofacitinib) during pregnancy: a review
JP Gisbert, M Chaparro - Drugs, 2020 - Springer
Two new biological drugs (vedolizumab and ustekinumab) and one small molecule
(tofacitinib) have been recently approved for the treatment of inflammatory bowel disease …
(tofacitinib) have been recently approved for the treatment of inflammatory bowel disease …
ECCO guidelines on the prevention, diagnosis, and management of infections in inflammatory bowel disease
T Kucharzik, P Ellul, T Greuter, JF Rahier… - Journal of Crohn's …, 2021 - academic.oup.com
The introduction and broad use of new immunosuppressive agents, including biologic
agents and JAK inhibitors, have revolutionised treatment of inflammatory bowel disease …
agents and JAK inhibitors, have revolutionised treatment of inflammatory bowel disease …
The use and impact of monoclonal antibody biologics during pregnancy
• Increasingly, pregnant patients with inflammatory or autoimmune diseases use monoclonal
antibody biologics before conception, during pregnancy and while breastfeeding.• A minority …
antibody biologics before conception, during pregnancy and while breastfeeding.• A minority …
Pregnancy outcomes in inflammatory bowel disease patients treated with vedolizumab, anti‐TNF or conventional therapy: results of the European CONCEIVE study
A Moens, CJ van der Woude… - Alimentary …, 2020 - Wiley Online Library
Background Women with inflammatory bowel diseases (IBD) often receive biologicals
during pregnancy to maintain disease remission. Data on outcome of vedolizumab‐exposed …
during pregnancy to maintain disease remission. Data on outcome of vedolizumab‐exposed …
Safety of ustekinumab or vedolizumab in pregnant inflammatory bowel disease patients: a multicentre cohort study
P Wils, P Seksik, C Stefanescu… - Alimentary …, 2021 - Wiley Online Library
Background The prevalence of inflammatory bowel diseases (IBD) is high in women of
childbearing age. Achieving clinical remission from conception to delivery using current …
childbearing age. Achieving clinical remission from conception to delivery using current …
Infliximab, adalimumab and vedolizumab concentrations across pregnancy and vedolizumab concentrations in infants following intrauterine exposure
Background The impact of pregnancy on levels of biologic agents in patients with IBD is
undefined and time to elimination in vedolizumab‐exposed infants is unknown. Aims To …
undefined and time to elimination in vedolizumab‐exposed infants is unknown. Aims To …
IBD in pregnancy: recent advances, practical management
CP Selinger, C Nelson-Piercy, A Fraser, V Hall… - Frontline …, 2021 - fg.bmj.com
Inflammatory bowel disease (IBD) poses complex issues in pregnancy, but with high-quality
care excellent pregnancy outcomes are achievable. In this article, we review the current …
care excellent pregnancy outcomes are achievable. In this article, we review the current …
New drugs for the treatment of IBD during conception, pregnancy, and lactation
The management of inflammatory bowel disease requires continuous medical therapy to
achieve and maintain disease control. Thus, women can be exposed to different drugs …
achieve and maintain disease control. Thus, women can be exposed to different drugs …
Vedolizumab clearance in neonates, susceptibility to infections and developmental milestones: a prospective multicentre population‐based cohort study
M Julsgaard, DC Baumgart… - Alimentary …, 2021 - Wiley Online Library
Background Little is known about the consequences of intrauterine exposure to, and the
post‐natal clearance of, vedolizumab. Aims To investigate the levels of vedolizumab in …
post‐natal clearance of, vedolizumab. Aims To investigate the levels of vedolizumab in …
Vaccines in Children Exposed to Biological Agents In Utero and/or During Breastfeeding: Are They Effective and Safe?
JP Gisbert, M Chaparro - Journal of Crohn's and Colitis, 2023 - academic.oup.com
Background Biological agents cross the placenta, resulting in detectable blood levels in the
neonate. Neonatal vaccinations are essential to prevent serious infections. Aim To review …
neonate. Neonatal vaccinations are essential to prevent serious infections. Aim To review …