Antimalarials from nature

K Kaur, M Jain, T Kaur, R Jain - Bioorganic & medicinal chemistry, 2009 - Elsevier
Malaria is a major public health problem mainly due to the development of resistance by the
most lethal causative parasitic species, Plasmodium falciparum to the mainstay drugs like …

The mechanistic targets of antifungal agents: an overview

TK Mazu, BA Bricker, H Flores-Rozas… - Mini reviews in …, 2016 - ingentaconnect.com
Pathogenic fungi are a major causative group for opportunistic infections (OIs). AIDS
patients and other immunocompromised individuals are at risk for OIs, which if not treated …

Indoloquinolines as scaffolds for drug discovery

J Lavrado, R Moreira, A Paulo - Current medicinal chemistry, 2010 - ingentaconnect.com
Traditional medicines have contributed greatly over the centuries to the discovery and
development of new therapeutic agents and indoloquinoline alkaloids may represent a new …

Antimicrobial study of newly synthesized 6-substituted indolo [1, 2-c] quinazolines

R Rohini, PM Reddy, K Shanker, A Hu… - European journal of …, 2010 - Elsevier
A new series of indolo [1, 2-c] quinazoline derivatives were prepared in good yield through
reaction of 2-(o-aminophenyl) indole with a variety of arylaldehydes. The structures of the …

Advancements in the synthesis of fused tetracyclic quinoline derivatives

RA Mekheimer, MA Al-Sheikh, HY Medrasi… - RSC advances, 2020 - pubs.rsc.org
Fused tetracyclic systems containing a quinoline nucleus represent an important class of
heterocyclic bioactive natural products and pharmaceuticals because of their significant and …

Design, synthesis, and antimicrobial activity of quindoline derivatives inspired by the cryptolepine alkaloid

QR Chu, YH He, C Tang, ZJ Zhang… - Journal of Agricultural …, 2022 - ACS Publications
Based on the structural characteristics of the cryptolepine alkaloid, a series of new
quindoline derivatives bearing various substituents were prepared and evaluated for their …

Quinoline-based anti-MRSA agents: Current development, structure-activity relationships, and mechanisms

H Yao, L Cui, H Liu, X Li, L Shen, R Yang, S Qin… - Chinese Chemical …, 2024 - Elsevier
Methicillin-resistant Staphylococcus aureus (MRSA), the most common pathogen in hospital
and community environments, can cause serious and even fatal infections. The antibiotics …

Indolo [3, 2-b] quinolines: synthesis, biological evaluation and structure activity-relationships

EVK Suresh Kumar, JR Etukala… - Mini reviews in …, 2008 - ingentaconnect.com
The tetracyclic indolo [3, 2-b] quinoline ring system constitutes an important structural moiety
in natural products exhibiting numerous biological activities. In particular, indolo [3, 2-b] …

AlCl3-Catalyzed Intramolecular Cyclization of N-Arylpropynamides with N-Sulfanylsuccinimides: Divergent Synthesis of 3-Sulfenyl Quinolin-2-ones and Azaspiro[4 …

WC Gao, T Liu, YF Cheng, HH Chang, X Li… - The Journal of …, 2017 - ACS Publications
Switchable ortho/ipso-cyclization of N-arylpropynamides induced with N-
sulfanylsuccinimides as general sulfur reagents is reported. In the presence of MeOH, para …

Construction of polyaromatic hydrocarbons containing sulfur and nitrogen via controllable domino reactions and DFT studies

B Wang, W Ding, L Zhang, X Meng - Organic Letters, 2022 - ACS Publications
Polyaromatic hydrocarbons (PHAs) containing heteroatoms have attracted considerable
attention due to their potential utility in electronic devices. This work reported a novel domino …