Pyroptosis‐Related Gene Model Predicts Prognosis and Immune Microenvironment for Non‐Small‐Cell Lung Cancer

L Luo, X Yao, J Xiang - Oxidative Medicine and Cellular …, 2022 - Wiley Online Library
Non‐small‐cell lung cancer (NSCLC) has a high incidence and mortality worldwide.
Moreover, it needs more accurate means for predicting prognosis and treatments. Pyroptosis …

CAPN1 promotes malignant behavior and erlotinib resistance mediated by phosphorylation of c‐Met and PIK3R2 via degrading PTPN1 in lung adenocarcinoma

Y Chen, J Tang, T Lu, F Liu - Thoracic cancer, 2020 - Wiley Online Library
Abstract Background Calpain 1 (CAPN1) has been found to be a promoter of cancer
progression. PTPN1 as a physiological target molecule of CAPN1 plays a dephosphorylated …

[HTML][HTML] Calpain system protein expression and activity in ovarian cancer

S Zhang, S Deen, SJ Storr, PS Chondrou… - Journal of Cancer …, 2019 - Springer
Purpose Expression of members of the calpain system are associated with clinical outcome
of patients with, amongst others, breast and ovarian cancers, with calpain-2 expression in …

High calpain-1 expression predicts a poor clinical outcome and contributes to tumor progression in pancreatic cancer patients

LM Yu, YS Zhu, CZ Xu, LL Zhou, ZX Xue… - Clinical and Translational …, 2019 - Springer
Background Pancreatic cancer (PC) is a highly aggressive and metastatic disease, with an
elevated mortality rate. It is, therefore, crucial to assess factors affecting the prognosis of PC …

Identification of Autophagy-Related Targets of Berberine against Non-Small Cell Lung Cancer and Their Correlation with Immune Cell Infiltration By Combining …

L Xu - Critical Reviews™ in Immunology, 2023 - dl.begellhouse.com
Objective: Non-small cell lung cancer (NSCLC) is the most common lung cancer type with
high incidence. This study aimed to reveal the anti-NSCLC mechanisms of berberine and …

Calpains: diverse functions but enigmatic

M Hosseini, H Najmabadi, K Kahrizi - Archives of Iranian Medicine, 2016 - journalaim.com
Calpains are a group of non-lysosomal Ca 2+-dependent cysteine proteases with numerous
substrates. Calpains have been identified in almost all eukaryotes and bacteria but not in …

[HTML][HTML] 17β-Estradiol promotes metastasis in triple-negative breast cancer through the Calpain/YAP/β-catenin signaling axis

X Niu, J Wang, J Liu, Q Yu, M Ci - Plos one, 2024 - journals.plos.org
β-catenin is an important regulator of malignant progression. 17β-Estradiol (E2), an
important sex hormone in women, promotes the growth and metastasis of triple-negative …

The nuclear transporter importin-11 regulates the Wnt/β-catenin pathway and acts as a tumor promoter in glioma

H Ni, D Ji, J Li, Z Zhao, J Zuo - International journal of biological …, 2021 - Elsevier
Karyopherins mediate the macromolecular transport between the cytoplasm and the nucleus
and participate in cancer progression. However, the role and mechanism of importin-11 …

The expression of calpain-1 and androgen receptor in breast cancer and their correlation with clinicopathological characteristics: An immunohistochemical …

K Rajković-Molek, E Mustać, M Avirović… - … -Research and Practice, 2020 - Elsevier
Breast cancer is a heterogeneous disease with different biological outcome and ability to
acquire resistance to therapy. The calpain family of proteases and androgen receptor (AR) …

Correlation of expression of Akt1 and E2F1 and their phosphorylated forms in breast cancer patients with clinicopathological parameters

SM Al-Bahlani, R Lakhtakia, SS Al-Jaaidi… - Journal of Molecular …, 2021 - Springer
Breast cancer is the leading cancer worldwide among women. Traditional
clinicopathological prognostic and predictive markers need refining to improve clinical …