Bioengineering virus‐like particles as vaccines

LHL Lua, NK Connors, F Sainsbury… - Biotechnology and …, 2014 - Wiley Online Library
Virus‐like particle (VLP) technology seeks to harness the optimally tuned immunostimulatory
properties of natural viruses while omitting the infectious trait. VLPs that assemble from a …

Platforms, advances, and technical challenges in virus-like particles-based vaccines

R Gupta, K Arora, SS Roy, A Joseph… - Frontiers in …, 2023 - frontiersin.org
Viral infectious diseases threaten human health and global stability. Several vaccine
platforms, such as DNA, mRNA, recombinant viral vectors, and virus-like particle-based …

Synthetic biology for bioengineering virus‐like particle vaccines

HK Charlton Hume, J Vidigal… - Biotechnology and …, 2019 - Wiley Online Library
Vaccination is the most effective method of disease prevention and control. Many viruses
and bacteria that once caused catastrophic pandemics (eg, smallpox, poliomyelitis …

Complete and cooperative in vitro assembly of computationally designed self-assembling protein nanomaterials

AJ Wargacki, TP Wörner, M van de Waterbeemd… - Nature …, 2021 - nature.com
Recent advances in computational methods have enabled the predictive design of self-
assembling protein nanomaterials with atomic-level accuracy. These design strategies focus …

Next generation vaccines and vectors: Designing downstream processes for recombinant protein‐based virus‐like particles

CL Effio, J Hubbuch - Biotechnology journal, 2015 - Wiley Online Library
In recent years, the development of novel recombinant virus‐like particles (VLPs) has been
generating new perspectives for the prevention of untreated and arising infectious diseases …

Exploiting virus-like particles as innovative vaccines against emerging viral infections

H Jeong, BL Seong - Journal of Microbiology, 2017 - Springer
Emerging viruses pose a major threat to humans and livestock with global public health and
economic burdens. Vaccination remains an effective tool to reduce this threat, and yet, the …

Virus-like particles: the future of microbial factories and cell-free systems as platforms for vaccine development

WA Rodríguez-Limas, K Sekar, KEJ Tyo - Current opinion in biotechnology, 2013 - Elsevier
Highlights▶ Microorganisms are inexpensive platforms to produce chimeric VLPs.▶
Bacteriophage-derived VLPs are excellent structures for drug delivery.▶ Microbial cell …

Insect cells as a production platform of complex virus-like particles

F Fernandes, AP Teixeira, N Carinhas… - Expert review of …, 2013 - Taylor & Francis
Virus-like particles (VLPs) are multiprotein structures that resemble the conformation of
native viruses but lack a viral genome, potentiating their application as safer and cheaper …

Plant viruses in plant molecular pharming: toward the use of enveloped viruses

A Ibrahim, V Odon, R Kormelink - Frontiers in Plant Science, 2019 - frontiersin.org
Plant molecular pharming has emerged as a reliable platform for recombinant protein
expression providing a safe and low-cost alternative to bacterial and mammalian cells …

Advances in virus-like particle-based SARS-CoV-2 vaccines

X Hao, F Yuan, X Yao - Frontiers in Cellular and Infection …, 2024 - frontiersin.org
The Coronavirus Disease 2019 (COVID-19) pandemic, caused by the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), has incurred devastating human and …