MicroRNAs as regulators of metabolic disease: pathophysiologic significance and emerging role as biomarkers and therapeutics

JA Deiuliis - International journal of obesity, 2016 - nature.com
The prevalence of overweight and obesity in developed and developing countries has
greatly increased the risk of insulin resistance and type 2 diabetes mellitus. It is evident from …

Adipogenesis: from stem cell to adipocyte

QQ Tang, MD Lane - Annual review of biochemistry, 2012 - annualreviews.org
Excessive caloric intake without a rise in energy expenditure promotes adipocyte
hyperplasia and adiposity. The rise in adipocyte number is triggered by signaling factors that …

The Lin28/let-7 axis regulates glucose metabolism

H Zhu, N Shyh-Chang, AV Segrè, G Shinoda, SP Shah… - Cell, 2011 - cell.com
The let-7 tumor suppressor microRNAs are known for their regulation of oncogenes, while
the RNA-binding proteins Lin28a/b promote malignancy by inhibiting let-7 biogenesis. We …

MicroRNA control of signal transduction

M Inui, G Martello, S Piccolo - Nature reviews Molecular cell biology, 2010 - nature.com
MicroRNAs (miRNAs) are integral elements in the post-transcriptional control of gene
expression. After the identification of hundreds of miRNAs, the challenge is now to …

The ZEB/miR‐200 feedback loop—a motor of cellular plasticity in development and cancer?

S Brabletz, T Brabletz - EMBO reports, 2010 - embopress.org
Epithelial‐to‐mesenchymal transition (EMT) is a fundamental process in development and
disease. Zinc‐finger enhancer binding (ZEB) transcription factors (ZEB1 and ZEB2) are …

Adipose organ development and remodeling

S Cinti - Comprehensive Physiology, 2018 - iris.univpm.it
During the last decades, research on adipose tissues has spread in parallel with the
extension of obesity. Several observations converged on the idea that adipose tissues are …

Role of microRNAs in obesity and obesity-related diseases

G Iacomino, A Siani - Genes & nutrition, 2017 - Springer
In recent years, the link between regulatory microRNAs (miRNAs) and diseases has been
the object of intensive research. miRNAs have emerged as key mediators of metabolic …

Genome, Functional Gene Annotation, and Nuclear Transformation of the Heterokont Oleaginous Alga Nannochloropsis oceanica CCMP1779

A Vieler, G Wu, CH Tsai, B Bullard, AJ Cornish… - PLoS …, 2012 - journals.plos.org
Unicellular marine algae have promise for providing sustainable and scalable biofuel
feedstocks, although no single species has emerged as a preferred organism. Moreover …

microRNA miR-27b impairs human adipocyte differentiation and targets PPARγ

M Karbiener, C Fischer, S Nowitsch… - Biochemical and …, 2009 - Elsevier
Obesity has emerged as a global health problem with more than 1.1 billion adults to be
classified as overweight or obese, and is associated with type 2 diabetes, cardiovascular …

miR-130 suppresses adipogenesis by inhibiting peroxisome proliferator-activated receptor γ expression

EK Lee, MJ Lee, K Abdelmohsen, W Kim… - … and cellular biology, 2011 - Taylor & Francis
Adipose tissue development is tightly regulated by altering gene expression. MicroRNAs are
strong posttranscriptional regulators of mammalian differentiation. We hypothesized that …