MicroRNAs as regulators of metabolic disease: pathophysiologic significance and emerging role as biomarkers and therapeutics
JA Deiuliis - International journal of obesity, 2016 - nature.com
The prevalence of overweight and obesity in developed and developing countries has
greatly increased the risk of insulin resistance and type 2 diabetes mellitus. It is evident from …
greatly increased the risk of insulin resistance and type 2 diabetes mellitus. It is evident from …
Adipogenesis: from stem cell to adipocyte
QQ Tang, MD Lane - Annual review of biochemistry, 2012 - annualreviews.org
Excessive caloric intake without a rise in energy expenditure promotes adipocyte
hyperplasia and adiposity. The rise in adipocyte number is triggered by signaling factors that …
hyperplasia and adiposity. The rise in adipocyte number is triggered by signaling factors that …
The Lin28/let-7 axis regulates glucose metabolism
The let-7 tumor suppressor microRNAs are known for their regulation of oncogenes, while
the RNA-binding proteins Lin28a/b promote malignancy by inhibiting let-7 biogenesis. We …
the RNA-binding proteins Lin28a/b promote malignancy by inhibiting let-7 biogenesis. We …
MicroRNA control of signal transduction
M Inui, G Martello, S Piccolo - Nature reviews Molecular cell biology, 2010 - nature.com
MicroRNAs (miRNAs) are integral elements in the post-transcriptional control of gene
expression. After the identification of hundreds of miRNAs, the challenge is now to …
expression. After the identification of hundreds of miRNAs, the challenge is now to …
The ZEB/miR‐200 feedback loop—a motor of cellular plasticity in development and cancer?
S Brabletz, T Brabletz - EMBO reports, 2010 - embopress.org
Epithelial‐to‐mesenchymal transition (EMT) is a fundamental process in development and
disease. Zinc‐finger enhancer binding (ZEB) transcription factors (ZEB1 and ZEB2) are …
disease. Zinc‐finger enhancer binding (ZEB) transcription factors (ZEB1 and ZEB2) are …
Adipose organ development and remodeling
S Cinti - Comprehensive Physiology, 2018 - iris.univpm.it
During the last decades, research on adipose tissues has spread in parallel with the
extension of obesity. Several observations converged on the idea that adipose tissues are …
extension of obesity. Several observations converged on the idea that adipose tissues are …
Role of microRNAs in obesity and obesity-related diseases
G Iacomino, A Siani - Genes & nutrition, 2017 - Springer
In recent years, the link between regulatory microRNAs (miRNAs) and diseases has been
the object of intensive research. miRNAs have emerged as key mediators of metabolic …
the object of intensive research. miRNAs have emerged as key mediators of metabolic …
Genome, Functional Gene Annotation, and Nuclear Transformation of the Heterokont Oleaginous Alga Nannochloropsis oceanica CCMP1779
Unicellular marine algae have promise for providing sustainable and scalable biofuel
feedstocks, although no single species has emerged as a preferred organism. Moreover …
feedstocks, although no single species has emerged as a preferred organism. Moreover …
microRNA miR-27b impairs human adipocyte differentiation and targets PPARγ
M Karbiener, C Fischer, S Nowitsch… - Biochemical and …, 2009 - Elsevier
Obesity has emerged as a global health problem with more than 1.1 billion adults to be
classified as overweight or obese, and is associated with type 2 diabetes, cardiovascular …
classified as overweight or obese, and is associated with type 2 diabetes, cardiovascular …
miR-130 suppresses adipogenesis by inhibiting peroxisome proliferator-activated receptor γ expression
EK Lee, MJ Lee, K Abdelmohsen, W Kim… - … and cellular biology, 2011 - Taylor & Francis
Adipose tissue development is tightly regulated by altering gene expression. MicroRNAs are
strong posttranscriptional regulators of mammalian differentiation. We hypothesized that …
strong posttranscriptional regulators of mammalian differentiation. We hypothesized that …