From genetics to response to injury: vascular smooth muscle cells in aneurysms and dissections of the ascending aorta
JB Michel, G Jondeau, DM Milewicz - Cardiovascular research, 2018 - academic.oup.com
Vascular smooth muscle cells (vSMCs) play a crucial role in both the pathogenesis of
Aneurysms and Dissections of the ascending thoracic aorta (TAAD) in humans and in the …
Aneurysms and Dissections of the ascending thoracic aorta (TAAD) in humans and in the …
Targeted molecular imaging of cardiovascular diseases by iron oxide nanoparticles
KX Vazquez-Prada, J Lam, D Kamato… - … and Vascular Biology, 2021 - Am Heart Assoc
Cardiovascular disease is one of the major contributors to global disease burden.
Atherosclerosis is an inflammatory process that involves the accumulation of lipids and …
Atherosclerosis is an inflammatory process that involves the accumulation of lipids and …
Endothelial dysfunction and cardiovascular disease: History and analysis of the clinical utility of the relationship
The endothelium is the single-cell monolayer that lines the entire vasculature. The
endothelium has a barrier function to separate blood from organs and tissues but also has …
endothelium has a barrier function to separate blood from organs and tissues but also has …
Pathologic intimal thickening in human atherosclerosis is formed by extracellular accumulation of plasma-derived lipids and dispersion of intimal smooth muscle cells
K Nakagawa, Y Nakashima - Atherosclerosis, 2018 - Elsevier
Background and aims Pathologic intimal thickening (PIT) is an important stage of
atherosclerosis that leads to atheroma. The present study aimed to clarify the pathogenesis …
atherosclerosis that leads to atheroma. The present study aimed to clarify the pathogenesis …
Insights on the pathogenesis of aneurysm through the study of hereditary aortopathies
Thoracic aortic aneurysms (TAA) are permanent and localized dilations of the aorta that
predispose patients to a life-threatening risk of aortic dissection or rupture. The identification …
predispose patients to a life-threatening risk of aortic dissection or rupture. The identification …
Tryptophan metabolites kynurenine and serotonin regulate fibroblast activation and fibrosis
Fibrosis is a pathological form of aberrant tissue repair, the complications of which account
for nearly half of all deaths in the industrialized world. All tissues are susceptible to fibrosis …
for nearly half of all deaths in the industrialized world. All tissues are susceptible to fibrosis …
The role of toll-like receptors in atherothrombotic cardiovascular disease
Toll-like receptors (TLRs) are dominant components of the innate immune system. Activated
by both pathogen-associated molecular patterns and damage-associated molecular …
by both pathogen-associated molecular patterns and damage-associated molecular …
Smad linker region phosphorylation is a signalling pathway in its own right and not only a modulator of canonical TGF-β signalling
Transforming growth factor (TGF)-β signalling pathways are intensively investigated
because of their diverse association with physiological and pathophysiological states. Smad …
because of their diverse association with physiological and pathophysiological states. Smad …
Transforming growth factor-β receptors: versatile mechanisms of ligand activation
Transforming growth factor-β (TGF-β) signaling is initiated by activation of transmembrane
TGF-β receptors (TGFBR), which deploys Smad2/3 transcription factors to control cellular …
TGF-β receptors (TGFBR), which deploys Smad2/3 transcription factors to control cellular …
Exploring the cardiac ECM during fibrosis: A new era with next-gen proteomics
Extracellular matrix (ECM) plays a critical role in maintaining elasticity in cardiac tissues.
Elasticity is required in the heart for properly pumping blood to the whole body …
Elasticity is required in the heart for properly pumping blood to the whole body …