Secretory IgA (SIgA) is the dominant antibody class in mucosal secretions. The majority of
plasma cells producing IgA are located within mucosal membranes lining the intestines …

CD8 T cells comprising the memory pool display considerable heterogeneity, with individual
cells differing in phenotype and function. This review will focus on our current understanding …

INTRODUCTION Laboratory mice are a mainstay of biomedical research and have been
instrumental for many important discoveries in the field of immunology. However, there are …

These guidelines are a consensus work of a considerable number of members of the
immunology and flow cytometry community. They provide the theory and key practical …

The discovery of T cells resident in diverse tissues has altered our understanding of
adaptive immunity to encompass site-specific responses mediated by tissue-adapted …

Influenza and other respiratory viral infections are the most common type of acute respiratory
infection. Viral infections predispose patients to secondary bacterial infections, which often …

Laboratory mice, while paramount for understanding basic biological phenomena, are
limited in modeling complex diseases of humans and other free-living mammals. Because …

Despite the prevalence and clinical importance of influenza, its long-term effect on lung
immunity is unclear. Here we describe that following viral clearance and clinical recovery, at …

Considerable advances have been made in recent years in understanding the generation
and function of memory T cells. Memory T cells are typically parsed into discreet subsets …

The human immune system is highly variable between individuals but relatively stable over
time within a given person. Recent conceptual and technological advances have enabled …