Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible of the
coronavirus disease 2019 (COVID-19) pandemic. Therapeutic options including …

Immune thrombocytopenia (ITP) is a complex autoimmune disease characterized by low
platelet counts. The pathogenesis of ITP remains unclear although both antibody-mediated …

Intravenous immunoglobulin (IVIG) preparations comprise pooled IgG antibodies from the
serum of thousands of donors and were initially used as an IgG replacement therapy in …

Placental transfer of maternal IgG antibodies to the fetus is an important mechanism that
provides protection to the infant while his/her humoral response is inefficient. IgG is the only …

Autoimmune encephalitis is one of the most rapidly growing research topics in neurology.
Along with discoveries of novel antibodies associated with the disease, clinical experience …

The neonatal Fc receptor for IgG (FcRn) has been well characterized in the transfer of
passive humoral immunity from a mother to her fetus. In addition, throughout life, FcRn …

Intravenous Immune Globulin in Autoimmune and Inflammatory Diseases | New England Journal
of Medicine Skip to main content The New England Journal of Medicine homepage Advanced …

Intravenous immunoglobulin (IVIg)—a preparation of polyclonal serum IgG pooled from
thousands of blood donors—has been used for nearly three decades, and is proving to be …

Self-reactive IgGs contribute to the pathology of autoimmune diseases, including systemic
lupus erythematosus and rheumatoid arthritis. Paradoxically, IgGs are used to treat …

Pathogenic immunoglobulin G (IgG) autoantibodies characterize some human autoimmune
diseases; their high concentration and long half-life are dependent on recycling by the …