ABL-family proteins comprise one of the best conserved branches of the tyrosine kinases.
Each ABL protein contains an SH3-SH2-TK (Src homology 3–Src homology 2–tyrosine …

Protein-protein interactions are essential for the assembly, regulation, and localization of
functional protein complexes in the cell. SAM domains are among the most abundant protein …

Oncogenic fusions in TRK family receptor tyrosine kinases have been identified in several
cancers and can serve as therapeutic targets. We identified ETV6–NTRK3, MYO5A–NTRK3 …

Oncogenic tyrosine kinase fusions involving the anaplastic lymphoma kinase (ALK) are
detected in numerous tumor types. Although more than 30 distinct 5′ fusion partner genes …

There is growing evidence supporting an inherited basis for susceptibility to acute
lymphoblastic leukemia (ALL) in children. In particular, we and others reported recurrent …

The ETV6–NTRK3 (TEL–TRKC) gene fusion was discovered by breakpoint analysis of the t
(12; 15)(p13; q25) translocation associated with congenital fibrosarcoma, a pediatric soft …

The formation of dynamic protein filaments contributes to various biological functions by
clustering individual molecules together and enhancing their binding to ligands. We report …

Secretory carcinomas of the breast are rare tumors with distinct histologic features, recurrent
t (12; 15)(p13; q25) translocation resulting in ETV6–NTRK3 gene fusion and indolent clinical …

Introduction• Tyrosine kinase inhibitors• Fusion gene structure and expression• Loss of wild‐
type alleles• Oligomerization triggers TK activation• Inhibitory domain deletion• Signalling …

Background Characterization of novel fusion genes in acute leukemia is important for
gaining information about leukemia genesis. We describe the characterization of a new …