Alzheimer's disease (AD) is the most common form of dementia, an eversible, progressive
disease that causes problems with memory, thinking, language, planning, and behavior …

Drosophila melanogaster provides a powerful genetic model system in which to investigate
the molecular mechanisms underlying neurodegenerative diseases. In this review, we …

Vesicular trafficking defects, particularly those in the autophagolysosomal system, have
been strongly implicated in the pathogenesis of Parkinson's disease and related α …

Glial engulfment of neuron-derived debris after trauma, during development, and in
neurodegenerative diseases supports nervous system functions. However, mechanisms …

Age-related impairment of macroautophagy/autophagy and loss of cardiac tissue
homeostasis contribute significantly to cardiovascular diseases later in life. MTOR …

Abstract The Smurf Assay (SA) was initially developed in the model organism Drosophila
melanogaster where a dramatic increase of intestinal permeability has been shown to occur …

Traumatic brain injury (TBI), caused by a sudden blow or jolt to the brain that disrupts normal
function, is an emerging health epidemic with∼ 2.5 million cases occurring annually in the …

In traumatic brain injury (TBI), the initial injury phase is followed by a secondary phase that
contributes to neurodegeneration, yet the mechanisms leading to neuropathology in vivo …

Traumatic brain injury (TBI) is the strongest environmental risk factor for the accelerated
development of neurodegenerative diseases. There are currently no therapeutics to address …

Aβ peptides derived from the amyloid precursor protein (APP) have been strongly implicated
in the pathogenesis of Alzheimer's disease. However, the normal function of APP and the …