Acetaminophen-related hepatotoxicity

C Bunchorntavakul, KR Reddy - Clinics in liver disease, 2013 - liver.theclinics.com
Acetaminophen (APAP or paracetamol or N-acetyl-p-aminophenol), a safe and effective
antipyretic and analgesic, has been extensively used around the world since 1955. It is …

Inflammation and nitro-oxidative stress as drivers of endocannabinoid system aberrations in mood disorders and schizophrenia

G Morris, L Sominsky, KR Walder, M Berk, W Marx… - Molecular …, 2022 - Springer
The endocannabinoid system (ECS) is composed of the endocannabinoid ligands
anandamide (AEA) and 2-arachidonoylgycerol (2-AG), their target cannabinoid receptors …

The neuroprotective role of coenzyme Q10 against lead acetate-induced neurotoxicity is mediated by antioxidant, anti-inflammatory and anti-apoptotic activities

AO S. Yousef, A A. Fahad, AE Abdel Moneim… - International journal of …, 2019 - mdpi.com
Heavy metal exposure, in lead (Pb) particularly, is associated with severe neuronal
impairment though oxidative stress mediated by reactive oxygen species, and antioxidants …

Dexamethasone as an anti-cancer or hepatotoxic

F Motafeghi, P Mortazavi… - Toxicology …, 2023 - Taylor & Francis
The linkage between inflammation and oxidative stress in liver damage has been proven
and is undeniable; dexamethasone with some antioxidants can reduce the toxicity of liver …

Coenzyme Q10 activates the antioxidant machinery and inhibits the inflammatory and apoptotic cascades against lead acetate-induced renal injury in rats

WA Al-Megrin, D Soliman, RB Kassab… - Frontiers in …, 2020 - frontiersin.org
The kidney is among the metabolic organs most susceptible to injury, particularly following
exposure to xenobiotics and heavy metals. We aimed to explore the potential protective …

Functions of coenzyme Q10 supplementation on liver enzymes, markers of systemic inflammation, and adipokines in patients affected by nonalcoholic fatty liver …

F Farsi, M Mohammadshahi, P Alavinejad… - Journal of the …, 2016 - Taylor & Francis
Background: Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disorder related to
inflammation. Coenzyme Q10 (CoQ10) is a natural compound that has recently been …

The preventive effects and the mechanisms of action of navel Orange peel hydroethanolic extract, naringin, and naringenin in N‐acetyl‐p‐aminophenol‐induced liver …

OM Ahmed, HI Fahim, HY Ahmed… - Oxidative medicine …, 2019 - Wiley Online Library
N‐Acetyl‐p‐aminophenol (APAP) or acetaminophen is the most common drug ingredient
worldwide. It is found in more than 600 different over‐the‐counter and prescription …

Coenzyme Q10 supplementation ameliorates inflammatory markers in patients with multiple sclerosis: a double blind, placebo, controlled randomized clinical trial

M Sanoobar, S Eghtesadi, A Azimi, M Khalili… - Nutritional …, 2015 - Taylor & Francis
Objectives Multiple sclerosis (MS) is an immune-mediated neurodegenerative disease of
central nervous system and recent studies show that inflammatory processes are highly …

Cubosomes as a potential oral drug delivery system for enhancing the hepatoprotective effect of coenzyme Q10

AM Mohsen, MM Younis, A Salama… - Journal of Pharmaceutical …, 2021 - Elsevier
Abstract Coenzyme Q10 (CoQ10) acts as an antioxidant that protects the cells by preventing
lipid peroxidation. Owing to its low solubility, CoQ10 has shown poor delivery properties and …

Probiotic Bacillus spores protect against acetaminophen induced acute liver injury in rats

MA Neag, A Catinean, DM Muntean, MR Pop… - Nutrients, 2020 - mdpi.com
Acetaminophen (APAP) is one of the most used analgesics and antipyretic agents in the
world. Intoxication with APAP is the main cause of acute liver toxicity in both the US and …