[HTML][HTML] PI3K/AKT signal pathway: a target of natural products in the prevention and treatment of Alzheimer's disease and Parkinson's disease

HZ Long, Y Cheng, ZW Zhou, HY Luo… - Frontiers in …, 2021 - frontiersin.org
Alzheimer's disease (AD) and Parkinson's disease (PD) are two typical neurodegenerative
diseases that increased with aging. With the emergence of aging population, the health …

The dialogue between neuroinflammation and adult neurogenesis: mechanisms involved and alterations in neurological diseases

M Amanollahi, M Jameie, A Heidari, N Rezaei - Molecular neurobiology, 2023 - Springer
Adult neurogenesis occurs mainly in the subgranular zone of the hippocampal dentate gyrus
and the subventricular zone of the lateral ventricles. Evidence supports the critical role of …

Neuroinflammation in neurological disorders: pharmacotherapeutic targets from bench to bedside

A Mishra, R Bandopadhyay, PK Singh, PS Mishra… - Metabolic Brain …, 2021 - Springer
Neuroinflammation is one of the host defensive mechanisms through which the nervous
system protects itself from pathogenic and or infectious insults. Moreover, neuroinflammation …

[HTML][HTML] The effect of curcumin on cognition in Alzheimer's disease and healthy aging: A systematic review of pre-clinical and clinical studies

SD Voulgaropoulou, T Van Amelsvoort, J Prickaerts… - Brain research, 2019 - Elsevier
Alzheimer's disease constitutes a growing cause of cognitive impairment in aging
population. Given that current treatments do not produce the desired therapeutic effects, the …

[HTML][HTML] Neuroinflammation and neurogenesis in Alzheimer's disease and potential therapeutic approaches

PS Sung, PY Lin, CH Liu, HC Su, KJ Tsai - International journal of …, 2020 - mdpi.com
In adult brain, new neurons are generated throughout adulthood in the subventricular zone
and the dentate gyrus; this process is commonly known as adult neurogenesis. The …

[HTML][HTML] Curcumin, hormesis and the nervous system

M Concetta Scuto, C Mancuso, B Tomasello… - Nutrients, 2019 - mdpi.com
Curcumin is a polyphenol compound extracted from the rhizome of Curcuma longa Linn
(family Zingiberaceae) commonly used as a spice to color and flavor food. Several …

Neuroprotective effects of curcumin in cerebral ischemia: cellular and molecular mechanisms

L Subedi, BP Gaire - ACS Chemical Neuroscience, 2021 - ACS Publications
Despite being a major global health concern, cerebral ischemia/stroke has limited
therapeutic options. Tissue plasminogen activator (tPA) is the only available medication to …

[HTML][HTML] The emerging role of curcumin in the modulation of TLR-4 signaling pathway: focus on neuroprotective and anti-rheumatic properties

MA Panaro, A Corrado, T Benameur, CF Paolo… - International Journal of …, 2020 - mdpi.com
Natural products have been used in medicine for thousands of years. Given their potential
health benefits, they have gained significant popularity in recent times. The administration of …

[HTML][HTML] Analogous β-carboline alkaloids harmaline and harmine ameliorate scopolamine-induced cognition dysfunction by attenuating acetylcholinesterase activity …

SP Li, YW Wang, SL Qi, YP Zhang, G Deng… - Frontiers in …, 2018 - frontiersin.org
The analogous β-carboline alkaloids, harmaline (HAL) and harmine (HAR), possess a
variety of biological properties, including acetylcholinesterase (AChE) inhibitory activity …

[HTML][HTML] Novel therapeutic delivery of nanocurcumin in central nervous system related disorders

E Panzarini, S Mariano, S Tacconi, E Carata, AM Tata… - Nanomaterials, 2020 - mdpi.com
Nutraceuticals represent complementary or alternative beneficial products to the expensive
and high-tech therapeutic tools in modern medicine. Nowadays, their medical or health …