Enhancers are short regulatory sequences bound by sequence-specific transcription factors
and play a major role in the spatiotemporal specificity of gene expression patterns in …

Fetal hemoglobin (HbF) can blunt the pathophysiology, temper the clinical course, and offer
prospects for curative therapy of sickle cell disease. This review focuses on (1) HbF …

Importance Sickle cell disease (SCD) is a monogenic disorder, yet clinical outcomes are
influenced by additional genetic factors. Despite decades of research, the genetics of SCD …

2020-05-07 First worldwide family litigation filed litigation Critical https://patents. darts-ip.
com/? family= 52105124&utm_source= google_patent&utm_medium …

Hematopoiesis is the process of blood cell formation starting from hematopoietic
stem/progenitor cells (HSPCs). The understanding of regulatory networks involved in …

Hemoglobinopathies though a monogenic disorder, show phenotypic variability. Hence,
understanding the genetics underlying the heritable sub-phenotypes of …

Fetal hemoglobin (HbF) has well‐known tempering effects on the symptoms of sickle cell
disease and its levels vary among patients with different haplotypes of the sickle hemoglobin …

β‐hemoglobin disorders, such as β‐thalassemia and sickle cell anemia are among the most
prevalent inherited genetic disorders worldwide. These disorders are caused by mutations …

Sickle cell anemia (SCA), albeit monogenic, has heterogeneous phenotypic expression,
mainly related to the level of hemoglobin F (HbF). No large cohort studies have ever …

The presence of high levels of fetal haemoglobin (HbF) provides well‐validated clinical
benefits to patients with sickle cell anaemia (SCA). Nevertheless it has been difficult to show …