Trans-Acting Small RNAs and Their Effects on Gene Expression in Escherichia coli and Salmonella enterica

J Hör, G Matera, J Vogel, S Gottesman, G Storz - EcoSal Plus, 2020 - Am Soc Microbiol
The last few decades have led to an explosion in our understanding of the major roles that
small regulatory RNAs (sRNAs) play in regulatory circuits and the responses to stress in …

Regulation of mRNA stability during bacterial stress responses

DA Vargas-Blanco, SS Shell - Frontiers in microbiology, 2020 - frontiersin.org
Bacteria have a remarkable ability to sense environmental changes, swiftly regulating their
transcriptional and posttranscriptional machinery as a response. Under conditions that …

Role of the 5′ end phosphorylation state for small RNA stability and target RNA regulation in bacteria

A Schilder, B Görke - Nucleic Acids Research, 2023 - academic.oup.com
In enteric bacteria, several small RNAs (sRNAs) including MicC employ endoribonuclease
RNase E to stimulate target RNA decay. A current model proposes that interaction of the …

A cooperative PNPase-Hfq-RNA carrier complex facilitates bacterial riboregulation

T Dendooven, D Sinha, A Roeselová, TA Cameron… - Molecular Cell, 2021 - cell.com
Polynucleotide phosphorylase (PNPase) is an ancient exoribonuclease conserved in the
course of evolution and is found in species as diverse as bacteria and humans …

Small RNAs as fundamental players in the transference of information during bacterial infectious diseases

JJ González Plaza - Frontiers in Molecular Biosciences, 2020 - frontiersin.org
Communication shapes life on Earth. Transference of information has played a paramount
role on the evolution of all living or extinct organisms since the appearance of life. Success …

Target recognition by RNase E RNA-binding domain AR2 drives sRNA decay in the absence of PNPase

D Sinha, NR De Lay - … of the National Academy of Sciences, 2022 - National Acad Sciences
The C-terminal domain (CTD) of the major endoribonuclease RNase E not only serves as a
scaffold for the central RNA decay machinery in gram-negative bacteria but also mediates …

Polynucleotide phosphorylase promotes the stability and function of Hfq-binding sRNAs by degrading target mRNA-derived fragments

TA Cameron, LM Matz, D Sinha… - Nucleic acids …, 2019 - academic.oup.com
In many Gram-negative and some Gram-positive bacteria, small regulatory RNAs (sRNAs)
that bind the RNA chaperone Hfq have a pivotal role in modulating virulence, stress …

Oxygen‐dependent regulation of SPI1 type three secretion system by small RNAs in Salmonella enterica serovar Typhimurium

K Kim, YA Golubeva, CK Vanderpool… - Molecular …, 2019 - Wiley Online Library
Salmonella Typhimurium induces inflammatory diarrhea and uptake into intestinal epithelial
cells using the Salmonella pathogenicity island 1 (SPI1) type III secretion system (T3SS) …

The impact of leadered and leaderless gene structures on translation efficiency, transcript stability, and predicted transcription rates in Mycobacterium smegmatis

TG Nguyen, DA Vargas-Blanco, LA Roberts… - Journal of …, 2020 - Am Soc Microbiol
Regulation of gene expression is critical for Mycobacterium tuberculosis to tolerate stressors
encountered during infection and for nonpathogenic mycobacteria such as Mycobacterium …

The essential role of mRNA degradation in understanding and engineering E. coli metabolism

C Roux, TA Etienne, E Hajnsdorf, D Ropers… - Biotechnology …, 2022 - Elsevier
Metabolic engineering strategies are crucial for the development of bacterial cell factories
with improved performance. Until now, optimal metabolic networks have been designed …