After induction and specification in the ectoderm, at the border of the neural plate, the neural
crest (NC) population leaves its original territory through a delamination process. Soon …

Epithelial–mesenchymal transition (EMT) is an important process during development by
which epithelial cells acquire mesenchymal, fibroblast-like properties and show reduced …

The underpinnings of cancer metastasis remain poorly understood, in part due to a lack of
tools for probing their emergence at high resolution. Here we present macsGESTALT, an …

Recurrent chromosomal rearrangements have not been well characterized in common
carcinomas. We used a bioinformatics approach to discover candidate oncogenic …

Chromosomal rearrangements fusing the androgen-regulated gene TMPRSS2 to the
oncogenic ETS transcription factor ERG occur in approximately 50% of prostate cancers, but …

Invasion, the hallmark of malignancy, consists in the translocation of tumour cells from the
initial neoplastic focus into neighbouring host tissues, and also allows tumour cells to …

ETS proteins are a group of evolutionarily related, DNA-binding transcriptional factors.
These proteins direct gene expression in diverse normal and disease states by binding to …

The homologous ETV1, ETV4 and ETV5 proteins form the PEA3 subfamily of ETS
transcription factors. In Ewing tumors, chromosomal translocations affecting ETV1 or ETV4 …

Cancer can be defined as a genetic disease, resulting as a consequence of multiple events
associated with initiation, promotion and metastatic growth. Cancer results from the loss of …

Ets1 belongs to the large family of the ETS domain family of transcription factors and is
involved in cancer progression. In most carcinomas, Ets1 expression is linked to poor …