In a previous development stage, mostly individual antibacterial activity was a target in the
optimization of biologically active compounds and antiseptic agents. Although this targeting …

Quinoline is a versatile pharmacophore, a privileged scaffold and an outstanding fused
heterocyclic compound with a wide range of pharmacological prospective such as …

Bacterial infections have seriously threatened public health especially with the increasing
resistance and the cliff-like decline of the number of newly approved antibacterial agents …

The quaternization of compounds has emerged as a promising molecular design strategy for
the development of antibiotics. Herein, we report the design, synthesis, antibacterial …

Abstract The ESKAPE (Escherichia coli/E. coli, Staphylococcus aureus/S. aureus, Klebsiella
pneumonia/K. pneumoniae, Acinetobacter Baumannii/A. baumannii, Pseudomonas …

In the modern scenario, the quinolone scaffold has emerged as a very potent motif
considering its clinical significance. Quinolones possess wide range of pharmacological …

A novel class of 7-thiazoxime quinolones was developed as potential antimicrobial agents
for the sake of bypassing resistance of quinolones. Biological assays revealed that some …

Bacterial infection is amongst the most common diseases in community and hospital
settings. Fluoroquinolones, exerting the antibacterial activity through binding to type II …

Bacterial DNA gyrase is a type II topoisomerase that can introduce negative supercoils to
DNA substrates and is a clinically-relevant target for the development of new antibacterials …

Although most of the heterocycles have been reported to possess a significant
pharmacological activity, only a few of them, namely quinoline derivatives, have exhibited …