Understanding and overcoming resistance to PARP inhibitors in cancer therapy
Developing novel targeted anticancer therapies is a major goal of current research. The use
of poly (ADP-ribose) polymerase (PARP) inhibitors in patients with homologous …
of poly (ADP-ribose) polymerase (PARP) inhibitors in patients with homologous …
BRCA mutations in ovarian and prostate cancer: bench to bedside
Simple Summary DNA damage is one of the hallmarks of cancer. Epithelial ovarian cancer
(EOC)—especially the high-grade serous subtype—harbors a defect in at least one DNA …
(EOC)—especially the high-grade serous subtype—harbors a defect in at least one DNA …
Repair pathway choices and consequences at the double-strand break
DNA double-strand breaks (DSBs) are cytotoxic lesions that threaten genomic integrity.
Failure to repair a DSB has deleterious consequences, including genomic instability and cell …
Failure to repair a DSB has deleterious consequences, including genomic instability and cell …
Unravelling the biology of SCLC: implications for therapy
Small-cell lung cancer (SCLC) is an aggressive malignancy associated with a poor
prognosis. First-line treatment has remained unchanged for decades, and a paucity of …
prognosis. First-line treatment has remained unchanged for decades, and a paucity of …
Harnessing DNA double-strand break repair for cancer treatment
A Trenner, AA Sartori - Frontiers in oncology, 2019 - frontiersin.org
DNA double-strand breaks (DSBs) are highly deleterious, with a single unrepaired DSB
being sufficient to trigger cell death. Compared to healthy cells, cancer cells have a higher …
being sufficient to trigger cell death. Compared to healthy cells, cancer cells have a higher …
RAD52 facilitates mitotic DNA synthesis following replication stress
R Bhowmick, S Minocherhomji, ID Hickson - Molecular cell, 2016 - cell.com
Homologous recombination (HR) is necessary to counteract DNA replication stress.
Common fragile site (CFS) loci are particularly sensitive to replication stress and undergo …
Common fragile site (CFS) loci are particularly sensitive to replication stress and undergo …
Homology-directed repair and the role of BRCA1, BRCA2, and related proteins in genome integrity and cancer
Germ-line and somatic mutations in genes that promote homology-directed repair (HDR),
especially BRCA1 and BRCA2, are frequently observed in several cancers, in particular …
especially BRCA1 and BRCA2, are frequently observed in several cancers, in particular …
PARP Inhibitor Activity Correlates with SLFN11 Expression and Demonstrates Synergy with Temozolomide in Small Cell Lung Cancer
Purpose: PARP inhibitors (PARPi) are a novel class of small molecule therapeutics for small
cell lung cancer (SCLC). Identification of predictors of response would advance our …
cell lung cancer (SCLC). Identification of predictors of response would advance our …
CDK12 inhibition reverses de novo and acquired PARP inhibitor resistance in BRCA wild-type and mutated models of triple-negative breast cancer
SF Johnson, C Cruz, AK Greifenberg, S Dust… - Cell reports, 2016 - cell.com
Although poly (ADP-ribose) polymerase (PARP) inhibitors are active in homologous
recombination (HR)-deficient cancers, their utility is limited by acquired resistance after …
recombination (HR)-deficient cancers, their utility is limited by acquired resistance after …
Targeting DNA damage response in cancer therapy
N Hosoya, K Miyagawa - Cancer science, 2014 - Wiley Online Library
Cancer chemotherapy and radiotherapy are designed to kill cancer cells mostly by inducing
DNA damage. DNA damage is normally recognized and repaired by the intrinsic DNA …
DNA damage. DNA damage is normally recognized and repaired by the intrinsic DNA …