Targeting MET in cancer: rationale and progress
E Gherardi, W Birchmeier, C Birchmeier… - Nature reviews …, 2012 - nature.com
Uncontrolled cell survival, growth, angiogenesis and metastasis are essential hallmarks of
cancer. Genetic and biochemical data have demonstrated that the growth and motility factor …
cancer. Genetic and biochemical data have demonstrated that the growth and motility factor …
Met, metastasis, motility and more
C Birchmeier, W Birchmeier, E Gherardi… - … reviews Molecular cell …, 2003 - nature.com
Hepatocyte growth factor/scatter factor and its receptor, the tyrosine kinase Met, arose late in
evolution and are unique to vertebrates. In spite of this, Met uses molecules such as Gab1 …
evolution and are unique to vertebrates. In spite of this, Met uses molecules such as Gab1 …
Structural basis of the activation of c-MET receptor
The c-MET receptor is a receptor tyrosine kinase (RTK) that plays essential roles in normal
cell development and motility. Aberrant activation of c-MET can lead to both tumors growth …
cell development and motility. Aberrant activation of c-MET can lead to both tumors growth …
Hepatocyte growth factor twenty years on: Much more than a growth factor
T Nakamura, K Sakai, T Nakamura… - Journal of …, 2011 - Wiley Online Library
Liver regeneration depends on the proliferation of mature hepatocytes. In the 1980s, the
method for the cultivation of mature hepatocytes provided an opportunity for the discovery of …
method for the cultivation of mature hepatocytes provided an opportunity for the discovery of …
[HTML][HTML] InlB-dependent internalization of Listeria is mediated by the Met receptor tyrosine kinase
The Listeria monocytogenes surface protein InlB promotes bacterial entry into mammalian
cells. Here, we identify a cellular surface receptor required for InlB-mediated entry …
cells. Here, we identify a cellular surface receptor required for InlB-mediated entry …
Heparan sulfate proteoglycans on the cell surface: versatile coordinators of cellular functions
S Tumova, A Woods, JR Couchman - … journal of biochemistry & cell biology, 2000 - Elsevier
Heparan sulfate proteoglycans are complex molecules composed of a core protein with
covalently attached glycosaminoglycan chains. While the protein part determines …
covalently attached glycosaminoglycan chains. While the protein part determines …
Heparan sulfate: growth control with a restricted sequence menu
JT Gallagher - The Journal of clinical investigation, 2001 - Am Soc Clin Investig
The sulfated domains of HS are the main regions involved in the recognition of growth
factors and other proteins. They are separated by flexible spacers of low sulfation. Although …
factors and other proteins. They are separated by flexible spacers of low sulfation. Although …
Structural basis of hepatocyte growth factor/scatter factor and MET signalling
The polypeptide growth factor, hepatocyte growth factor/scatter factor (HGF/SF), shares the
multidomain structure and proteolytic mechanism of activation of plasminogen and other …
multidomain structure and proteolytic mechanism of activation of plasminogen and other …
[HTML][HTML] Flexibility and small pockets at protein–protein interfaces: new insights into druggability
The transient assembly of multiprotein complexes mediates many aspects of cell regulation
and signalling in living organisms. Modulation of the formation of these complexes through …
and signalling in living organisms. Modulation of the formation of these complexes through …
Delivery of an engineered HGF fragment in an extracellular matrix-derived hydrogel prevents negative LV remodeling post-myocardial infarction
SB Sonnenberg, AA Rane, CJ Liu, N Rao, G Agmon… - Biomaterials, 2015 - Elsevier
Hepatocyte growth factor (HGF) has been shown to have anti-fibrotic, pro-angiogenic, and
cardioprotective effects; however, it is highly unstable and expensive to manufacture …
cardioprotective effects; however, it is highly unstable and expensive to manufacture …