Oxidative cyclizations are important transformations that occur widely during natural product
biosynthesis. The transformations from acyclic precursors to cyclized products can afford …

Many oxidation–reduction (redox) enzymes, particularly oxygenases, have roles in reactions
that make and break C–C bonds. The list includes cytochrome P450 and other heme-based …

Psychoactive natural products play an integral role in the modern world. The tremendous
structural complexity displayed by such molecules confers diverse biological activities of …

Biological oxidations form the basis of life on earth by utilizing organic compounds as
electron donors to drive the generation of metabolic energy carriers, such as ATP. Oxidative …

This account focuses on the application of ω-transaminases, lyases, and oxidases for the
preparation of amines considering mainly work from our own lab. Examples are given to …

Berberine bridge enzyme-like oxidases are often involved in natural product biosynthesis
and are seen as essential enzymes for the generation of intricate pharmacophores. These …

Natural product discovery efforts have focused primarily on microbial biosynthetic gene
clusters (BGCs) containing large multimodular polyketide synthases and nonribosomal …

Covering: 2015 to 2022 In this review, we discuss the recent advances in the use of
isotopically labelled compounds to investigate the biosynthesis of polyketides, non …

Alkaloids are not only one of the most intensively studied classes of natural products, their
wide spectrum of pharmacological activities also makes them indispensable drug …

L-Lactate oxidase (LOX) is a member of α‑hydroxy acid-oxidizing enzymes, and it catalyzes
oxidation of l-lactate into pyruvate using flavin mononucleotide (FMN) as cofactor. Based on …