Strategies to access biosynthetic novelty in bacterial genomes for drug discovery
F Hemmerling, J Piel - Nature Reviews Drug Discovery, 2022 - nature.com
Bacteria provide a rich source of natural products with potential therapeutic applications,
such as novel antibiotic classes or anticancer drugs. Bioactivity-guided screening of …
such as novel antibiotic classes or anticancer drugs. Bioactivity-guided screening of …
[HTML][HTML] In situ identification of environmental microorganisms with Raman spectroscopy
Microorganisms in natural environments are crucial in maintaining the material and energy
cycle and the ecological balance of the environment. However, it is challenging to delineate …
cycle and the ecological balance of the environment. However, it is challenging to delineate …
Strong and Elastic Membranes via Hydrogen Bonding Directed Self‐Assembly of Atomically Precise Nanoclusters
Abstract 2D nanomaterials have provided an extraordinary palette of mechanical, electrical,
optical, and catalytic properties. Ultrathin 2D nanomaterials are classically produced via …
optical, and catalytic properties. Ultrathin 2D nanomaterials are classically produced via …
Ramanome technology platform for label-free screening and sorting of microbial cell factories at single-cell resolution
Phenotypic profiling of natural, engineered or synthetic cells has increasingly become a
bottleneck in the mining and engineering of cell factories. Single-cell phenotyping …
bottleneck in the mining and engineering of cell factories. Single-cell phenotyping …
Polarization-sensitive stimulated Raman scattering imaging resolves amphotericin B orientation in Candida membrane
Ergosterol-targeting amphotericin B (AmB) is the first line of defense for life-threatening
fungal infections. Two models have been proposed to illustrate AmB assembly in the cell …
fungal infections. Two models have been proposed to illustrate AmB assembly in the cell …
Raman spectroscopic signatures of carotenoids and polyenes enable label-free visualization of microbial distributions within pink biofilms
H Horiue, M Sasaki, Y Yoshikawa, M Toyofuku… - Scientific reports, 2020 - nature.com
Pink biofilms are multispecies microbial communities that are commonly found in moist
household environments. The development of this pink stain is problematic from an …
household environments. The development of this pink stain is problematic from an …
Imaging bacterial interspecies chemical interactions by surface-enhanced Raman scattering
G Bodelón, V Montes-García, C Costas, I Pérez-Juste… - ACS …, 2017 - ACS Publications
Microbes produce bioactive chemical compounds to influence the physiology and growth of
their neighbors, and our understanding of their biological activities may be enhanced by our …
their neighbors, and our understanding of their biological activities may be enhanced by our …
Machine learning-assisted single-cell Raman fingerprinting for in situ and nondestructive classification of prokaryotes
Accessing enormous uncultivated microorganisms (microbial dark matter) in various Earth
environments requires accurate, nondestructive classification, and molecular understanding …
environments requires accurate, nondestructive classification, and molecular understanding …
Raman scattering: from structural biology to medical applications
This is a review of relevant Raman spectroscopy (RS) techniques and their use in structural
biology, biophysics, cells, and tissues imaging towards development of various medical …
biology, biophysics, cells, and tissues imaging towards development of various medical …
Micromolding of amphotericin-B-loaded methoxyethylene–maleic anhydride copolymer microneedles
S Azizi Machekposhti, AK Nguyen, L Vanderwal… - Pharmaceutics, 2022 - mdpi.com
Biocompatible and biodegradable materials have been used for fabricating polymeric
microneedles to deliver therapeutic drug molecules through the skin. Microneedles have …
microneedles to deliver therapeutic drug molecules through the skin. Microneedles have …