Strategies to access biosynthetic novelty in bacterial genomes for drug discovery

F Hemmerling, J Piel - Nature Reviews Drug Discovery, 2022 - nature.com
Bacteria provide a rich source of natural products with potential therapeutic applications,
such as novel antibiotic classes or anticancer drugs. Bioactivity-guided screening of …

[HTML][HTML] In situ identification of environmental microorganisms with Raman spectroscopy

D Cui, L Kong, Y Wang, Y Zhu, C Zhang - Environmental Science and …, 2022 - Elsevier
Microorganisms in natural environments are crucial in maintaining the material and energy
cycle and the ecological balance of the environment. However, it is challenging to delineate …

Strong and Elastic Membranes via Hydrogen Bonding Directed Self‐Assembly of Atomically Precise Nanoclusters

A Som, A Griffo, I Chakraborty, H Hähl, B Mondal… - Small, 2022 - Wiley Online Library
Abstract 2D nanomaterials have provided an extraordinary palette of mechanical, electrical,
optical, and catalytic properties. Ultrathin 2D nanomaterials are classically produced via …

Ramanome technology platform for label-free screening and sorting of microbial cell factories at single-cell resolution

Y He, X Wang, B Ma, J Xu - Biotechnology Advances, 2019 - Elsevier
Phenotypic profiling of natural, engineered or synthetic cells has increasingly become a
bottleneck in the mining and engineering of cell factories. Single-cell phenotyping …

Polarization-sensitive stimulated Raman scattering imaging resolves amphotericin B orientation in Candida membrane

PT Dong, C Zong, Z Dagher, J Hui, J Li, Y Zhan… - Science …, 2021 - science.org
Ergosterol-targeting amphotericin B (AmB) is the first line of defense for life-threatening
fungal infections. Two models have been proposed to illustrate AmB assembly in the cell …

Raman spectroscopic signatures of carotenoids and polyenes enable label-free visualization of microbial distributions within pink biofilms

H Horiue, M Sasaki, Y Yoshikawa, M Toyofuku… - Scientific reports, 2020 - nature.com
Pink biofilms are multispecies microbial communities that are commonly found in moist
household environments. The development of this pink stain is problematic from an …

Imaging bacterial interspecies chemical interactions by surface-enhanced Raman scattering

G Bodelón, V Montes-García, C Costas, I Pérez-Juste… - ACS …, 2017 - ACS Publications
Microbes produce bioactive chemical compounds to influence the physiology and growth of
their neighbors, and our understanding of their biological activities may be enhanced by our …

Machine learning-assisted single-cell Raman fingerprinting for in situ and nondestructive classification of prokaryotes

N Kanno, S Kato, M Ohkuma, M Matsui, W Iwasaki… - Iscience, 2021 - cell.com
Accessing enormous uncultivated microorganisms (microbial dark matter) in various Earth
environments requires accurate, nondestructive classification, and molecular understanding …

Raman scattering: from structural biology to medical applications

AV Vlasov, NL Maliar, SV Bazhenov, EI Nikelshparg… - Crystals, 2020 - mdpi.com
This is a review of relevant Raman spectroscopy (RS) techniques and their use in structural
biology, biophysics, cells, and tissues imaging towards development of various medical …

Micromolding of amphotericin-B-loaded methoxyethylene–maleic anhydride copolymer microneedles

S Azizi Machekposhti, AK Nguyen, L Vanderwal… - Pharmaceutics, 2022 - mdpi.com
Biocompatible and biodegradable materials have been used for fabricating polymeric
microneedles to deliver therapeutic drug molecules through the skin. Microneedles have …