The use of nanoparticles (NPs) in nanomedicine holds great promise for the treatment of
diseases for which conventional therapies present serious limitations. Additionally, NPs can …

The common and persistent failures to translate promising preclinical drug candidates into
clinical success highlight the limited effectiveness of disease models currently used in drug …

The complex interaction of cells with biomaterials (ie, materiobiology) plays an increasingly
pivotal role in the development of novel implants, biomedical devices, and tissue …

This article reviews the application of electric circuit methods for the analysis of pressure-
driven microfluidic networks with an emphasis on concentration-and flow-dependent …

In a forest of a hundred thousand trees, no two leaves are alike. Similarly, no two cells in a
genetically identical group are the same. This heterogeneity at the single-cell level has been …

Substantial evidence shows that the heterogeneity of individual cells within a genetically
identical population can be critical to their chance of survival. Methods that use average …

Microfluidics, a toolbox comprising methods for precise manipulation of fluids at small length
scales (micrometers to millimeters), has become useful for manipulating cells. Its uses range …

Single-cell analysis (SCA) has been increasingly recognized as the key technology for the
elucidation of cellular functions, which are not accessible from bulk measurements on the …

We present a highly parallel microfluidic approach for contacting single cell pairs. The
approach combines a differential fluidic resistance trapping method with a novel cellular …

A core challenge in biomedical and life science research is to decipher cell-to-cell
differences under pathological progression or external perturbation. Microfluidics-based …