De novo lipogenesis in the liver in health and disease: more than just a shunting yard for glucose

FWB Sanders, JL Griffin - Biological Reviews, 2016 - Wiley Online Library
Hepatic de novo lipogenesis (DNL) is the biochemical process of synthesising fatty acids
from acetyl‐CoA subunits that are produced from a number of different pathways within the …

Diet-induced models of non-alcoholic fatty liver disease: food for thought on sugar, fat, and cholesterol

JM Eng, JL Estall - Cells, 2021 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) affects approximately 1 in 4 people worldwide and
is a major burden to health care systems. A major concern in NAFLD research is lack of …

Fructose stimulated de novo lipogenesis is promoted by inflammation

J Todoric, G Di Caro, S Reibe, DC Henstridge… - Nature …, 2020 - nature.com
Benign hepatosteatosis, affected by lipid uptake, de novo lipogenesis and fatty acid (FA)
oxidation, progresses to non-alcoholic steatohepatitis (NASH) on stress and inflammation. A …

Randomised clinical trial: gut microbiome biomarkers are associated with clinical response to a low FODMAP diet in children with the irritable bowel syndrome

BP Chumpitazi, JL Cope, EB Hollister… - Alimentary …, 2015 - Wiley Online Library
Background A low fermentable oligosaccharides, disaccharides, monosaccharides and
polyols (FODMAP) diet can ameliorate symptoms in adult irritable bowel syndrome (IBS) …

[图书][B] The story of the human body: evolution, health, and disease

D Lieberman - 2014 - books.google.com
A landmark book of popular science that gives us a lucid and engaging account of how the
human body evolved over millions of years—with charts and line drawings throughout.“ …

Increasing prevalence of nonalcoholic fatty liver disease among United States adolescents, 1988-1994 to 2007-2010

JA Welsh, S Karpen, MB Vos - The Journal of pediatrics, 2013 - Elsevier
OBJECTIVE: To assess recent trends in nonalcoholic fatty liver disease (NAFLD) prevalence
among US adolescents. STUDY DESIGN: Cross-sectional data from 12 714 12-19 year olds …

The role of fructose in the pathogenesis of NAFLD and the metabolic syndrome

JS Lim, M Mietus-Snyder, A Valente… - Nature reviews …, 2010 - nature.com
Nonalcoholic fatty liver disease (NAFLD) is the most frequent liver disease worldwide, and is
commonly associated with the metabolic syndrome. Secular trends in the prevalence of …

Evidence that 'food addiction'is a valid phenotype of obesity

C Davis, C Curtis, RD Levitan, JC Carter, AS Kaplan… - Appetite, 2011 - Elsevier
There is growing evidence of 'food addiction'(FA) in sugar-and fat-bingeing animals. The
purpose of this study was to investigate the legitimacy of this disorder in the human …

[PDF][PDF] Increased fructose consumption is associated with fibrosis severity in patients with nonalcoholic fatty liver disease

MF Abdelmalek, A Suzuki, C Guy, A Unalp‐Arida… - …, 2010 - Wiley Online Library
The rising incidence of obesity and diabetes coincides with a marked increase in fructose
consumption. Fructose consumption is higher in individuals with nonalcoholic fatty liver …

Chronic diarrhea: diagnosis and management

LR Schiller, DS Pardi, JH Sellin - Clinical Gastroenterology and Hepatology, 2017 - Elsevier
Chronic diarrhea is a common problem affecting up to 5% of the population at a given time.
Patients vary in their definition of diarrhea, citing loose stool consistency, increased …