Enzymatically oxidized lipids are a specific group of biomolecules that function as key
signaling mediators and hormones, regulating various cellular and physiological processes …

'Eicosanoid'is a term coined to describe compounds derived from C 20 fatty acids [1]. The
term is now generally used to identify the paracrine hormones derived from free arachidonic …

ABSTRACT Phospholipase A 2 (PLA 2) plays crucial roles in diverse cellular responses,
including phospholipid digestion and metabolism, host defense and signal transduction …

Receptor-stimulated arachidonic acid (AA) mobilization in P388D 1 macrophages consists
of a transient phase in which AA accumulates in the cell and a sustained phase in which AA …

We examined the relative contributions of five distinct mammalian phospholipase A 2 (PLA
2) enzymes (cytosolic PLA 2 (cPLA 2; type IV), secretory PLA 2 s (sPLA 2 s; types IIA, V, and …

Background & Aims: Neonatal necrotizing enterocolitis (NEC) is a devastating
gastrointestinal disease of premature infants partly caused by intestinal bacterial …

Biological membranes, primarily composed of lipids, envelop each living cell. The intricate
composition and organization of membrane lipids, including the variety of fatty acids they …

Over the past few decades, the fundamental concept that the in vivo modulation of levels of
arachidonic acid (AA) is intimately linked to cellular function and human disease has been …

The rat mast cell line RBL-2H3. 1 contains an 85-kDa cytosolic phospholipase A 2 (cPLA 2)
that is very likely involved in liberating arachidonate from membrane phospholipid for the …

Mammalian secreted phospholipases A 2 (sPLA2s) comprise a group of at least eight
enzymes, including the recently identified group X sPLA2. A bacterial expression system …