Polymeric nanoparticle vaccines to combat emerging and pandemic threats
D Wibowo, SHT Jorritsma, ZJ Gonzaga, B Evert… - Biomaterials, 2021 - Elsevier
Subunit vaccines are more advantageous than live attenuated vaccines in terms of safety
and scale-up manufacture. However, this often comes as a trade-off to their efficacy. Over …
and scale-up manufacture. However, this often comes as a trade-off to their efficacy. Over …
Polymer-based nanosystems—A versatile delivery approach
AG Niculescu, AM Grumezescu - Materials, 2021 - mdpi.com
Polymer-based nanoparticles of tailored size, morphology, and surface properties have
attracted increasing attention as carriers for drugs, biomolecules, and genes. By protecting …
attracted increasing attention as carriers for drugs, biomolecules, and genes. By protecting …
Advances in vaccine delivery systems against viral infectious diseases
Although vaccines are available for many infectious diseases, there are still unresolved
infectious diseases that threaten global public health. In particular, the rapid spread of …
infectious diseases that threaten global public health. In particular, the rapid spread of …
Integrating biomaterials and immunology to improve vaccines against infectious diseases
L Yenkoidiok-Douti, CM Jewell - ACS Biomaterials Science & …, 2020 - ACS Publications
Despite the success of vaccines in preventing many infectious diseases, effective vaccines
against pathogens with ongoing challenges—such as HIV, malaria, and tuberculosis …
against pathogens with ongoing challenges—such as HIV, malaria, and tuberculosis …
Co-delivery of Interleukin-12 and doxorubicin loaded Nano-delivery system for enhanced immunotherapy with polarization toward M1-type Macrophages
T Li, Z Liu, X Fu, Y Chen, S Zhu, J Zhang - European Journal of …, 2022 - Elsevier
Chemo-immunotherapy has gained increasing attention as one of the most promising
combination therapy strategies to battle cancer. In this study, the therapeutic nanoparticles …
combination therapy strategies to battle cancer. In this study, the therapeutic nanoparticles …
The incorporation of cationic property and immunopotentiator in poly (lactic acid) microparticles promoted the immune response against chronic hepatitis B
T Lu, F Hu, H Yue, T Yang, G Ma - Journal of Controlled Release, 2020 - Elsevier
Biodegradable microparticles (MPs) as vaccine adjuvants have sparked the passion of
researchers in recent decades. However, it is still a huge challenge to develop an efficient …
researchers in recent decades. However, it is still a huge challenge to develop an efficient …
In vitro and in vivo evaluation of immune response of poly (lactic acid) nanoparticles with different end groups
Y Gao, J Yang, Y Zhang, Y Zhao, X Zhao… - International Journal of …, 2023 - Elsevier
Abstract Poly (lactic acid)(PLA) has excellent properties of biodegradability and
biocompatibility, which is a US Food and Drug Administration (FDA) approved biopolymer …
biocompatibility, which is a US Food and Drug Administration (FDA) approved biopolymer …
Engineered nanoparticles inside a microparticle oral system for enhanced mucosal and systemic immunity
Antigen delivery through an oral route requires overcoming multiple challenges, including
gastrointestinal enzymes, mucus, and epithelial tight junctions. Although each barrier has a …
gastrointestinal enzymes, mucus, and epithelial tight junctions. Although each barrier has a …
Novel therapeutic approaches for the management of hepatitis infections
A Damodaran, SM Zachariah, SC Nair - Therapeutic Delivery, 2024 - Taylor & Francis
Hepatitis B virus (HBV) & hepatitis C virus (HCV) infection is a substantial reason for
morbidity and mortality around the world. Chronic hepatitis B (CHB) infection is connected …
morbidity and mortality around the world. Chronic hepatitis B (CHB) infection is connected …
Process Optimization of Scaled-Up Production and Biosafety Evaluation of the Dimethyl-Dioctadecyl-Ammonium Bromide/Poly (lactic acid) Nano-Vaccine
H Yang, Y Gao, M Liu, J Ma, Q Lu - Journal of Functional Biomaterials, 2024 - mdpi.com
Nano-adjuvant vaccines could induce immune responses and enhance immunogenicity.
However, the application and manufacturing of nano-adjuvant is hampered by its …
However, the application and manufacturing of nano-adjuvant is hampered by its …