Polymeric nanoparticle vaccines to combat emerging and pandemic threats

D Wibowo, SHT Jorritsma, ZJ Gonzaga, B Evert… - Biomaterials, 2021 - Elsevier
Subunit vaccines are more advantageous than live attenuated vaccines in terms of safety
and scale-up manufacture. However, this often comes as a trade-off to their efficacy. Over …

Polymer-based nanosystems—A versatile delivery approach

AG Niculescu, AM Grumezescu - Materials, 2021 - mdpi.com
Polymer-based nanoparticles of tailored size, morphology, and surface properties have
attracted increasing attention as carriers for drugs, biomolecules, and genes. By protecting …

Advances in vaccine delivery systems against viral infectious diseases

D Kim, Y Wu, YB Kim, YK Oh - Drug Delivery and Translational Research, 2021 - Springer
Although vaccines are available for many infectious diseases, there are still unresolved
infectious diseases that threaten global public health. In particular, the rapid spread of …

Integrating biomaterials and immunology to improve vaccines against infectious diseases

L Yenkoidiok-Douti, CM Jewell - ACS Biomaterials Science & …, 2020 - ACS Publications
Despite the success of vaccines in preventing many infectious diseases, effective vaccines
against pathogens with ongoing challenges—such as HIV, malaria, and tuberculosis …

Co-delivery of Interleukin-12 and doxorubicin loaded Nano-delivery system for enhanced immunotherapy with polarization toward M1-type Macrophages

T Li, Z Liu, X Fu, Y Chen, S Zhu, J Zhang - European Journal of …, 2022 - Elsevier
Chemo-immunotherapy has gained increasing attention as one of the most promising
combination therapy strategies to battle cancer. In this study, the therapeutic nanoparticles …

The incorporation of cationic property and immunopotentiator in poly (lactic acid) microparticles promoted the immune response against chronic hepatitis B

T Lu, F Hu, H Yue, T Yang, G Ma - Journal of Controlled Release, 2020 - Elsevier
Biodegradable microparticles (MPs) as vaccine adjuvants have sparked the passion of
researchers in recent decades. However, it is still a huge challenge to develop an efficient …

In vitro and in vivo evaluation of immune response of poly (lactic acid) nanoparticles with different end groups

Y Gao, J Yang, Y Zhang, Y Zhao, X Zhao… - International Journal of …, 2023 - Elsevier
Abstract Poly (lactic acid)(PLA) has excellent properties of biodegradability and
biocompatibility, which is a US Food and Drug Administration (FDA) approved biopolymer …

Engineered nanoparticles inside a microparticle oral system for enhanced mucosal and systemic immunity

SS Surwase, SMS Shahriar, JM An, JH Ha… - … Applied Materials & …, 2022 - ACS Publications
Antigen delivery through an oral route requires overcoming multiple challenges, including
gastrointestinal enzymes, mucus, and epithelial tight junctions. Although each barrier has a …

Novel therapeutic approaches for the management of hepatitis infections

A Damodaran, SM Zachariah, SC Nair - Therapeutic Delivery, 2024 - Taylor & Francis
Hepatitis B virus (HBV) & hepatitis C virus (HCV) infection is a substantial reason for
morbidity and mortality around the world. Chronic hepatitis B (CHB) infection is connected …

Process Optimization of Scaled-Up Production and Biosafety Evaluation of the Dimethyl-Dioctadecyl-Ammonium Bromide/Poly (lactic acid) Nano-Vaccine

H Yang, Y Gao, M Liu, J Ma, Q Lu - Journal of Functional Biomaterials, 2024 - mdpi.com
Nano-adjuvant vaccines could induce immune responses and enhance immunogenicity.
However, the application and manufacturing of nano-adjuvant is hampered by its …