A review on Alzheimer's disease pathophysiology and its management: an update
A Kumar, A Singh - Pharmacological reports, 2015 - Elsevier
Alzheimer's disease acknowledged as progressive multifarious neurodegenerative disorder,
is the leading cause of dementia in late adult life. Pathologically it is characterized by …
is the leading cause of dementia in late adult life. Pathologically it is characterized by …
[HTML][HTML] Histone deacetylase 6 in cancer
T Li, C Zhang, S Hassan, X Liu, F Song, K Chen… - Journal of hematology & …, 2018 - Springer
Histone acetylation and deacetylation are important epigenetic mechanisms that regulate
gene expression and transcription. Histone deacetylase 6 (HDAC6) is a unique member of …
gene expression and transcription. Histone deacetylase 6 (HDAC6) is a unique member of …
Therapeutics of Alzheimer's disease: Past, present and future
Alzheimer's disease (AD) is the most common cause of dementia worldwide. The etiology is
multifactorial, and pathophysiology of the disease is complex. Data indicate an exponential …
multifactorial, and pathophysiology of the disease is complex. Data indicate an exponential …
The molecular basis for the pharmacokinetics and pharmacodynamics of curcumin and its metabolites in relation to cancer
M Heger, RF van Golen, M Broekgaarden… - Pharmacological …, 2014 - ASPET
This review addresses the oncopharmacological properties of curcumin at the molecular
level. First, the interactions between curcumin and its molecular targets are addressed on …
level. First, the interactions between curcumin and its molecular targets are addressed on …
[HTML][HTML] Curcumin suppresses soluble tau dimers and corrects molecular chaperone, synaptic, and behavioral deficits in aged human tau transgenic mice
The mechanisms underlying Tau-related synaptic and cognitive deficits and the
interrelationships between Tau species, their clearance pathways, and synaptic impairments …
interrelationships between Tau species, their clearance pathways, and synaptic impairments …
Natural products as important tyrosine kinase inhibitors
B Yin, DM Fang, XL Zhou, F Gao - European journal of medicinal chemistry, 2019 - Elsevier
As an important source of drugs, natural products play an important role in the discovery and
development of new drugs. More than 60% of anti-tumor drugs are closely related to natural …
development of new drugs. More than 60% of anti-tumor drugs are closely related to natural …
[HTML][HTML] Dietary phytochemicals, HDAC inhibition, and DNA damage/repair defects in cancer cells
Genomic instability is a common feature of cancer etiology. This provides an avenue for
therapeutic intervention, since cancer cells are more susceptible than normal cells to DNA …
therapeutic intervention, since cancer cells are more susceptible than normal cells to DNA …
Development and therapeutic impact of HDAC6-selective inhibitors
S Dallavalle, C Pisano, F Zunino - Biochemical pharmacology, 2012 - Elsevier
Histone deacetylases (HDAC) play a key role in regulating gene expression by
deacetylating histones. Some HDAC isoforms can also modulate the function of nonhistone …
deacetylating histones. Some HDAC isoforms can also modulate the function of nonhistone …
From natural products to HDAC inhibitors: An overview of drug discovery and design strategy
X Qiu, L Zhu, H Wang, Y Tan, Z Yang, L Yang… - Bioorganic & Medicinal …, 2021 - Elsevier
Histone deacetylases (HDACs) play a key role in the homeostasis of protein acetylation in
histones and have recently emerged as a therapeutic target for numerous diseases. The …
histones and have recently emerged as a therapeutic target for numerous diseases. The …
[HTML][HTML] Polyphenols as promising drugs against main breast cancer signatures
Breast cancer is one of the most common neoplasms worldwide, and in spite of clinical and
pharmacological advances, it is still a clinical problem, causing morbidity and mortality. On …
pharmacological advances, it is still a clinical problem, causing morbidity and mortality. On …