Alzheimer's disease acknowledged as progressive multifarious neurodegenerative disorder,
is the leading cause of dementia in late adult life. Pathologically it is characterized by …

Histone acetylation and deacetylation are important epigenetic mechanisms that regulate
gene expression and transcription. Histone deacetylase 6 (HDAC6) is a unique member of …

Alzheimer's disease (AD) is the most common cause of dementia worldwide. The etiology is
multifactorial, and pathophysiology of the disease is complex. Data indicate an exponential …

This review addresses the oncopharmacological properties of curcumin at the molecular
level. First, the interactions between curcumin and its molecular targets are addressed on …

The mechanisms underlying Tau-related synaptic and cognitive deficits and the
interrelationships between Tau species, their clearance pathways, and synaptic impairments …

As an important source of drugs, natural products play an important role in the discovery and
development of new drugs. More than 60% of anti-tumor drugs are closely related to natural …

Genomic instability is a common feature of cancer etiology. This provides an avenue for
therapeutic intervention, since cancer cells are more susceptible than normal cells to DNA …

Histone deacetylases (HDAC) play a key role in regulating gene expression by
deacetylating histones. Some HDAC isoforms can also modulate the function of nonhistone …

Histone deacetylases (HDACs) play a key role in the homeostasis of protein acetylation in
histones and have recently emerged as a therapeutic target for numerous diseases. The …

Breast cancer is one of the most common neoplasms worldwide, and in spite of clinical and
pharmacological advances, it is still a clinical problem, causing morbidity and mortality. On …