Abstract N-acylethanolamines (NAEs), including N-palmitoylethanolamine (PEA), N-
oleoylethanolamine (OEA), N-arachidonoylethanolamine (AEA, anandamide), N …

The phospholipase A2 (PLA2) superfamily contains more than 50 enzymes in mammals that
are subdivided into several distinct families on a structural and biochemical basis. In …

Abstract In essence,“phospholipase A 2”(PLA 2) means a group of enzymes that release
fatty acids and lysophospholipids by hydrolyzing the sn-2 position of glycerophospholipids …

Abstract The endocannabinoids 2-arachidonoyl-glycerol (2-AG) and N-arachidonoyl-
ethanolamine (AEA) are eicosanoids implicated in numerous physiological processes like …

The endocannabinoid system is involved in signal transduction in mammals. It comprises
principally G protein-coupled cannabinoid receptors and their endogenous agonists, called …

The endocannabinoid system (ECS) comprises two cognate endocannabinoid receptors
referred to as CB1R and CB2R. ECS dysregulation is apparent in neurodegenerative/neuro …

Among the phospholipase A 2 (PLA 2) superfamily, group IVA cytosolic PLA 2 (cPLA 2 α) is
currently attracting much attention as a central regulator of arachidonic acid (AA) metabolism …

Chronic inflammation in Alzheimer's disease (AD) has been recently identified as a major
contributor to disease pathogenesis. Once activated, microglial cells, which are brain …

Psoriasis is an inflammatory disorder characterized by keratinocyte hyper‐proliferation and
Th17‐type immune responses. However, the roles of bioactive lipids and the regulation of …

Abstract N-Acyl-phosphatidylethanolamines (NAPEs), a minor class of membrane
glycerophospholipids, accumulate along with their bioactive metabolites, N …