[HTML][HTML] Anandamide and other N-acylethanolamines: A class of signaling lipids with therapeutic opportunities
Abstract N-acylethanolamines (NAEs), including N-palmitoylethanolamine (PEA), N-
oleoylethanolamine (OEA), N-arachidonoylethanolamine (AEA, anandamide), N …
oleoylethanolamine (OEA), N-arachidonoylethanolamine (AEA, anandamide), N …
Updating Phospholipase A2 Biology
M Murakami, H Sato, Y Taketomi - Biomolecules, 2020 - mdpi.com
The phospholipase A2 (PLA2) superfamily contains more than 50 enzymes in mammals that
are subdivided into several distinct families on a structural and biochemical basis. In …
are subdivided into several distinct families on a structural and biochemical basis. In …
The phospholipase A2 superfamily as a central hub of bioactive lipids and beyond
M Murakami - Pharmacology & therapeutics, 2023 - Elsevier
Abstract In essence,“phospholipase A 2”(PLA 2) means a group of enzymes that release
fatty acids and lysophospholipids by hydrolyzing the sn-2 position of glycerophospholipids …
fatty acids and lysophospholipids by hydrolyzing the sn-2 position of glycerophospholipids …
[HTML][HTML] Biosynthesis and metabolism of endocannabinoids and their congeners from the monoacylglycerol and N-acyl-ethanolamine families
Abstract The endocannabinoids 2-arachidonoyl-glycerol (2-AG) and N-arachidonoyl-
ethanolamine (AEA) are eicosanoids implicated in numerous physiological processes like …
ethanolamine (AEA) are eicosanoids implicated in numerous physiological processes like …
Roles of endocannabinoids and endocannabinoid-like molecules in energy homeostasis and metabolic regulation: a nutritional perspective
SMK Rahman, T Uyama, Z Hussain… - Annual Review of …, 2021 - annualreviews.org
The endocannabinoid system is involved in signal transduction in mammals. It comprises
principally G protein-coupled cannabinoid receptors and their endogenous agonists, called …
principally G protein-coupled cannabinoid receptors and their endogenous agonists, called …
The endocannabinoidome in neuropsychiatry: Opportunities and potential risks
G Morris, K Walder, S Kloiber, P Amminger… - Pharmacological …, 2021 - Elsevier
The endocannabinoid system (ECS) comprises two cognate endocannabinoid receptors
referred to as CB1R and CB2R. ECS dysregulation is apparent in neurodegenerative/neuro …
referred to as CB1R and CB2R. ECS dysregulation is apparent in neurodegenerative/neuro …
Segregated functions of two cytosolic phospholipase A2 isoforms (cPLA2α and cPLA2ε) in lipid mediator generation
M Murakami, R Takamiya, Y Miki, N Sugimoto… - Biochemical …, 2022 - Elsevier
Among the phospholipase A 2 (PLA 2) superfamily, group IVA cytosolic PLA 2 (cPLA 2 α) is
currently attracting much attention as a central regulator of arachidonic acid (AA) metabolism …
currently attracting much attention as a central regulator of arachidonic acid (AA) metabolism …
Microglial endocannabinoid signalling in AD
L Scipioni, F Ciaramellano, V Carnicelli, A Leuti… - Cells, 2022 - mdpi.com
Chronic inflammation in Alzheimer's disease (AD) has been recently identified as a major
contributor to disease pathogenesis. Once activated, microglial cells, which are brain …
contributor to disease pathogenesis. Once activated, microglial cells, which are brain …
Group IVE cytosolic phospholipase A2 limits psoriatic inflammation by mobilizing the anti‐inflammatory lipid N‐acylethanolamine
L Liang, R Takamiya, Y Miki, K Heike… - The FASEB …, 2022 - Wiley Online Library
Psoriasis is an inflammatory disorder characterized by keratinocyte hyper‐proliferation and
Th17‐type immune responses. However, the roles of bioactive lipids and the regulation of …
Th17‐type immune responses. However, the roles of bioactive lipids and the regulation of …
Formation of N-acyl-phosphatidylethanolamines by cytosolic phospholipase A2ε in an ex vivo murine model of brain ischemia
SMK Rahman, Z Hussain, K Morito, N Takahashi… - … et Biophysica Acta (BBA …, 2022 - Elsevier
Abstract N-Acyl-phosphatidylethanolamines (NAPEs), a minor class of membrane
glycerophospholipids, accumulate along with their bioactive metabolites, N …
glycerophospholipids, accumulate along with their bioactive metabolites, N …