I discuss advances in the cell cycle in the 21 years since cyclin was discovered. The
surprising redundancy amongst the classical cyclins (A, B, and E) and cyclin-dependent …

Oxidative stress and the damage that results from it have been implicated in a wide number
of disease processes including atherosclerosis, autoimmune disorders, neuronal …

The bcr–abl oncogene, present in 95% of patients with chronic myelogenous leukemia
(CML), has been implicated as the cause of this disease. A compound, designed to inhibit …

Abstract γ-Irradiation of human diploid fibroblasts in the G1 interval caused arrest of the cell
cycle prior to S phase. This cell cycle block was correlated with a lack of activation of both …

We have produced extracts of frog eggs that can perform multiple cell cycles in vitro.
Destruction of the endogenous messenger RNA arrests the extracts in interphase. The …

When individual seedlings of Datura ferox and Sinapis alba were transferred to populations
formed by plants of similar stature, they responded with an increase in the rate of stem …

The nuclear lamina is an intermediate filament-type network underlying the inner nuclear
membrane. Phosphorylation of lamin proteins is believed to cause lamina disassembly …

The p34cdc2 protein kinase is known to regulate important transitions in the eukaryotic cell
cycle. We have identified 10 human protein kinases based on their structural relation to …

The study of female preferences and the evolution of male traits has until recently centered
on genetic coevolutionary mechanisms. An alternative mechanism posits that a preference …

Three mouse cyclin-like (CYL) genes were lsolated, two of which are regulated by colony-
stimulating factor 1 (CSF-1) during the G1 phase of the macrophage cell cycle. CSF-1 …