Mutations in Notch signaling pathway members cause developmental phenotypes that affect
the liver, skeleton, heart, eye, face, kidney, and vasculature. Notch associated disorders …

This review critically discusses the most recent advances in the role of Notch signaling in
liver development, homeostasis, and disease. It is now clear that the significance of Notch in …

Aberrant hepatocyte Notch activity is critical to the development of nonalcoholic
steatohepatitis (NASH)–induced liver fibrosis, but mechanisms underlying Notch reactivation …

In the mammalian liver, bile is transported to the intestine through an intricate network of bile
ducts. Notch signaling is required for normal duct formation, but its mode of action has been …

Notch signaling regulates a vast array of crucial developmental processes. It is therefore not
surprising that mutations in genes encoding Notch receptors or ligands lead to a variety of …

The bone marrow (BM) microenvironment is composed of multiple niche cells that, by
producing paracrine factors, maintain and regenerate the hematopoietic stem cell (HSC) …

Tissue regeneration is a process by which the remaining cells of an injured organ regrow to
offset the missed cells. This field is relatively a new discipline that has been a focus of …

Liver development requires two linked processes: differentiation of the various hepatic cell
types from their embryonic progenitors and the arrangement of those cells into structures …

The Notch ligand Jagged1 (Jag1) is essential for vascular remodeling and has been linked
to congenital heart disease in humans, but its precise role in various cell types of the …

Mutations in the human Notch ligand jagged 1 (JAG1) result in a multi-system disorder
called Alagille syndrome (AGS). AGS is chiefly characterized by a paucity of intrahepatic bile …