The value of antimicrobial peptides in the age of resistance
M Magana, M Pushpanathan, AL Santos… - The lancet infectious …, 2020 - thelancet.com
Accelerating growth and global expansion of antimicrobial resistance has deepened the
need for discovery of novel antimicrobial agents. Antimicrobial peptides have clear …
need for discovery of novel antimicrobial agents. Antimicrobial peptides have clear …
Antimicrobial peptides: An alternative to traditional antibiotics
S Ji, F An, T Zhang, M Lou, J Guo, K Liu, Y Zhu… - European Journal of …, 2024 - Elsevier
As antibiotic-resistant bacteria and genes continue to emerge, the identification of effective
alternatives to traditional antibiotics has become a pressing issue. Antimicrobial peptides …
alternatives to traditional antibiotics has become a pressing issue. Antimicrobial peptides …
Viral afterlife: SARS-CoV-2 as a reservoir of immunomimetic peptides that reassemble into proinflammatory supramolecular complexes
Y Zhang, V Bharathi, T Dokoshi… - Proceedings of the …, 2024 - National Acad Sciences
It is unclear how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection
leads to the strong but ineffective inflammatory response that characterizes severe …
leads to the strong but ineffective inflammatory response that characterizes severe …
Accelerating antibiotic discovery through artificial intelligence
MCR Melo, JRMA Maasch… - Communications …, 2021 - nature.com
By targeting invasive organisms, antibiotics insert themselves into the ancient struggle of the
host-pathogen evolutionary arms race. As pathogens evolve tactics for evading antibiotics …
host-pathogen evolutionary arms race. As pathogens evolve tactics for evading antibiotics …
Recent advances in design of antimicrobial peptides and polypeptides toward clinical translation
The recent outbreaks of infectious diseases caused by multidrug-resistant pathogens have
sounded a piercing alarm for the need of new effective antimicrobial agents to guard public …
sounded a piercing alarm for the need of new effective antimicrobial agents to guard public …
Externalized histone H4 orchestrates chronic inflammation by inducing lytic cell death
C Silvestre-Roig, Q Braster, K Wichapong, EY Lee… - Nature, 2019 - nature.com
The perpetuation of inflammation is an important pathophysiological contributor to the global
medical burden. Chronic inflammation is promoted by non-programmed cell death,; …
medical burden. Chronic inflammation is promoted by non-programmed cell death,; …
Deep learning improves antimicrobial peptide recognition
Motivation Bacterial resistance to antibiotics is a growing concern. Antimicrobial peptides
(AMPs), natural components of innate immunity, are popular targets for developing new …
(AMPs), natural components of innate immunity, are popular targets for developing new …
Computer-aided design of antimicrobial peptides: are we generating effective drug candidates?
MH Cardoso, RQ Orozco, SB Rezende… - Frontiers in …, 2020 - frontiersin.org
Antimicrobial peptides (AMPs), especially antibacterial peptides, have been widely
investigated as potential alternatives to antibiotic-based therapies. Indeed, naturally …
investigated as potential alternatives to antibiotic-based therapies. Indeed, naturally …
AI applications through the whole life cycle of material discovery
We provide a review of machine learning (ML) tools for material discovery and sophisticated
applications of different ML strategies. Although there have been a few published reviews on …
applications of different ML strategies. Although there have been a few published reviews on …
Machine learning designs non-hemolytic antimicrobial peptides
Machine learning (ML) consists of the recognition of patterns from training data and offers
the opportunity to exploit large structure–activity databases for drug design. In the area of …
the opportunity to exploit large structure–activity databases for drug design. In the area of …