The Wnt/β-catenin pathway comprises a family of proteins that play critical roles in
embryonic development and adult tissue homeostasis. The deregulation of Wnt/β-catenin …

The Wnt/β-catenin signaling pathway exerts integral roles in embryogenesis and adult
homeostasis. Aberrant activation of the pathway is implicated in growth-associated diseases …

Purpose The overall response of cisplatin-based chemotherapy in bladder urothelial
carcinoma (BUC) remains unsatisfactory due to the complex pathological subtypes, genomic …

The Wnt/β-catenin signaling pathway is a growth control pathway involved in various
biological processes as well as the development and progression of cancer. Colorectal …

Liquid–liquid Phase Separation (LLPS) of proteins and nucleic acids has emerged as a new
paradigm in the study of cellular activities. It drives the formation of liquid-like condensates …

Cell cycle checkpoints secure ordered progression from one cell cycle phase to the next.
They are important to signal cell stress and DNA lesions and to stop cell cycle progression …

Dissecting the myriad regulatory mechanisms controlling eukaryotic transcripts from
production to degradation requires quantitative measurements of mRNA flow across the cell …

MYC-driven medulloblastomas are highly aggressive childhood brain tumors, however, the
molecular and genetic events triggering MYC amplification and malignant transformation …

Background PARP inhibitors (PARPi) benefit only a fraction of breast cancer patients with
BRCA mutations, and their efficacy is even more limited in triple-negative breast cancer …

Super-enhancers (SEs) consist of a cluster of many enhancers bound to a great number of
transcription factors. They are critical cis-regulatory elements that determine the identity of …