Cellular senescence is a permanent state of cell cycle arrest that promotes tissue
remodeling during development and after injury, but can also contribute to the decline of the …

An increase in life expectancy in developed countries has led to a surge of chronic aging-
related diseases. In the last few decades, several studies have provided evidence of the …

Skin aging is induced and sustained by chronological aging and photoaging. Aging skin
pigmentation such as mottled pigmentation (senile lentigo) and melasma are typical signs of …

Pancreatic ductal adenocarcinoma (PDAC) has one of the most dismal prognoses of all
cancers due to its late manifestation and resistance to current therapies. Accumulating …

The locomotor system comprises skeletal muscles and bones with active metabolism and
cellular turnover. Chronic locomotor system disorders gradually arising with aging are …

Aging biomarkers are a combination of biological parameters to (i) assess age-related
changes,(ii) track the physiological aging process, and (iii) predict the transition into a …

Ambient air particulate matter (PM) induces senescence in human skin cells. However, the
underlying mechanisms remain largely unknown. We investigated how epigenetic …

Intimal hyperplasia, the key event of arterial restenosis, is a result of vascular smooth muscle
cell (VSMC) proliferation and migration. Previous studies have demonstrated that total …

Hypoxia-induced pulmonary hypertension is a life-threatening disease arising from a
progressive increase in pulmonary vascular resistance, irreversible pulmonary vascular …

Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in childhood. Recently,
we demonstrated the overexpression of both DNA methyltransferase 3A (DNMT3A) and 3B …