Desmosomes are intercellular junctions, which preserve tissue integrity during homeostatic
and stress conditions. These functions rely on their unique structural properties, which …

Pemphigus vulgaris (PV) is an autoimmune bullous skin disease caused primarily by
autoantibodies (PV-IgG) against the desmosomal adhesion proteins desmoglein (Dsg) 1 …

Tissue integrity is crucial for maintaining the homeostasis of living organisms. Abnormalities
that affect sites of cell-cell contact can cause a variety of debilitating disorders. The …

Hair loss in early childhood represents a broad differential diagnosis which can be a
diagnostic and therapeutic challenge for a physician. It is important to consider the diagnosis …

Hair shaft disorders are characterized by congenital or acquired abnormalities of the hair
shaft. The objective was to review the literature regarding the prognosis and treatment …

Scalp is a unique location for pemphigus because of the abundance of desmogleins
localized in hair follicles. Scalp involvement is observed in up to 60% of patients in the …

Split-hand and foot malformation (SHFM; MIM 183600) is a rare human genetic limb
malformation. It is characterized by missing digital rays in the hands and feet. SHFMs vary in …

Objective: To determine the role of variants in BRCA1 gene in breast cancer development,
women of Pakistani origin, diagnosed with breast cancer, were screened for variants in the …

Split-hand/split-foot malformation (SHFM), also known as ectrodactyly is a rare genetic
disorder. It is a clinically and genetically heterogeneous group of limb malformations …

This chapter is a comprehensive review of potential causes of alopecia or hair overgrowth
that physicians may see in the paediatric population. It begins with an overview of the …