Abstract α‐Crystallin, a prominent member of small heat shock protein (sHsp) family and a
major structural protein of the eye lens is a large polydisperse oligomer of two isoforms, αA …

Background The findings that α-crystallins are multi-functional proteins with diverse
biological functions have generated considerable interest in understanding their role in …

α-Crystallin is a member of the family of small heat-shock proteins (sHSP) and is composed
of two subunits, αA-crystallin and αB-crystallin, which exhibit molecular chaperone-like …

Mice expressing variants of superoxide dismutase-1 (SOD1) encoding C-terminal truncation
mutations linked to familial amyotrophic lateral sclerosis (FALS) have begun to define the …

α-Crystallin, a predominant protein of the ocular lens, is composed of two subunits, αA and
αB. Of these, αB-crystallin has been shown to present widely in non-lenticular tissues while …

Purpose.: Small heat shock proteins (sHsps) have a critical role under stress conditions to
maintain cellular homeostasis by their involvement in protein-folding and cytoprotection. The …

Purpose: A decline in the chaperone-like activity of eye lens α-crystallin in diabetic
conditions has been reported. In this study, we investigated whether curcumin, a dietary …

Abstract αB-Crystallin is a protein chaperone with anti-apoptotic and anti-inflammatory
activity that is apically secreted in exosomes by polarized human retinal pigment epithelium …

Age-related cataract (ARC) is a multifactorial disease and the leading cause of blindness
worldwide. Genetic predisposition in association with other etiological factors may contribute …

Purpose This research aims to probe the interaction of α-crystallin with a model of human,
porcine, and mouse lens-lipid membranes. Methods Cholesterol/model of human lens-lipid …