Movement is accomplished by the controlled activation of motor unit populations. Our
understanding of motor unit physiology has been derived from experimental work on the …

It is clear from non-human animal work that spinal motoneurones undergo endurance
training (chronic) and locomotor (acute) related changes in their electrical properties and …

To explore the link between bioenergetics and motor neuron degeneration, we used a
computational model in which detailed morphology and ion conductance are paired with …

In amyotrophic lateral sclerosis (ALS) the large motoneurons that innervate the fast-
contracting muscle fibers (F-type motoneurons) are vulnerable and degenerate in …

The dendrites of spinal motoneurones are highly active, generating a strong persistent
inward current (PIC) that has an enormous impact on processing of synaptic input. The PIC …

In the motor system there is a complex interplay between cortical structures and spinal cord
lower motor neurons (LMN). In this system both inhibitory and excitatory neurons have …

This work characterizes the properties of wild-type (WT) mouse motoneurons in the second
postnatal week and compares these at the same age and in the same conditions to those of …

The ability to generate human-induced pluripotent stem cell (hiPSC)-derived neural cells
displaying region-specific phenotypes is of particular interest for modeling central nervous …

Since their discovery in the late 19th century our conception of motoneurons has steadily
evolved. Motoneurons share the same general function: they drive the contraction of muscle …

Appropriate scaling of motor output from mouse to humans is essential. The motoneurons
that generate all motor output are, however, very different in rodents compared with humans …