In eukaryotes, the translation initiation codon is generally identified by the scanning
mechanism, wherein every triplet in the messenger RNA leader is inspected for …

Brain-derived neurotrophic factor (BDNF) is an important regulator of synaptic transmission
and long-term potentiation (LTP) in the hippocampus and in other brain regions, playing a …

Translational control in eukaryotic cells is critical for gene regulation during nutrient
deprivation and stress, development and differentiation, nervous system function, aging, and …

Translation initiation in eukaryotes is a highly regulated and complex stage of gene
expression. It requires the action of at least 12 initiation factors, many of which are known to …

Long-lasting forms of synaptic plasticity and memory are dependent on new protein
synthesis. Recent advances obtained from genetic, physiological, pharmacological, and …

The correct translation of mRNA depends critically on the ability to initiate at the right AUG
codon. For most mRNAs in eukaryotic cells, this is accomplished by the scanning …

The 5′ mRNA cap structure is essential for efficient gene expression from yeast to human. It
plays a critical role in all aspects of the life cycle of an mRNA molecule. Capping occurs co …

Recent advances in our understanding of both the regulation of components of the
translational machinery and the upstream signalling pathways that modulate them have …

In eukaryotes, protein synthesis initiates primarily by a mechanism that requires a modified
nucleotide 'cap'on the mRNA and also proteins that recruit and position the ribosome. Many …

In mammalian cells, nonsense-mediated mRNA decay (NMD) generally requires that
translation terminates sufficiently upstream of a post-splicing exon junction complex (EJC) …