A biological definition of neuronal α-synuclein disease: towards an integrated staging system for research
Parkinson's disease and dementia with Lewy bodies are currently defined by their clinical
features, with α-synuclein pathology as the gold standard to establish the definitive …
features, with α-synuclein pathology as the gold standard to establish the definitive …
Genetic architecture of Parkinson's disease subtypes–Review of the literature
The heterogeneity of Parkinson's disease (PD) has been recognized since its description by
James Parkinson over 200 years ago. The complexity of motor and non-motor PD …
James Parkinson over 200 years ago. The complexity of motor and non-motor PD …
Mitochondrial complex I as a pathologic and therapeutic target for Parkinson's disease
KP Tryphena, US Nikhil, P Pinjala… - ACS Chemical …, 2023 - ACS Publications
The prevalence of Parkinson's disease (PD) continues to increase despite substantial
research. Mounting evidence states that dysfunctional mitochondrial bioenergetics play a …
research. Mounting evidence states that dysfunctional mitochondrial bioenergetics play a …
Peripheral inflammatory immune response differs among sporadic and familial Parkinson's disease
L Muñoz-Delgado, D Macías-García… - npj Parkinson's …, 2023 - nature.com
Peripheral inflammatory immune responses are thought to play a major role in the
pathogenesis of Parkinson's disease (PD). The neutrophil-to-lymphocyte ratio (NLR), a …
pathogenesis of Parkinson's disease (PD). The neutrophil-to-lymphocyte ratio (NLR), a …
Valosin containing protein (VCP): initiator, modifier, and potential drug target for neurodegenerative diseases
S Chu, X Xie, C Payan, U Stochaj - Molecular Neurodegeneration, 2023 - Springer
The AAA+ ATPase valosin containing protein (VCP) is essential for cell and organ
homeostasis, especially in cells of the nervous system. As part of a large network, VCP …
homeostasis, especially in cells of the nervous system. As part of a large network, VCP …
Key genes and convergent pathogenic mechanisms in Parkinson disease
Parkinson disease (PD) is a neurodegenerative disorder marked by the preferential
dysfunction and death of dopaminergic neurons in the substantia nigra. The onset and …
dysfunction and death of dopaminergic neurons in the substantia nigra. The onset and …
Towards a global view of Parkinson's disease genetics
Parkinson's disease (PD) is a global health challenge, yet historically studies of PD have
taken place predominantly in European populations. Recent genetics research conducted in …
taken place predominantly in European populations. Recent genetics research conducted in …
Autophagy in Parkinson's disease
L Nechushtai, D Frenkel, R Pinkas-Kramarski - Biomolecules, 2023 - mdpi.com
Parkinson's disease (PD) is a devastating disease associated with accumulation of α-
synuclein (α-Syn) within dopaminergic neurons, leading to neuronal death. PD is …
synuclein (α-Syn) within dopaminergic neurons, leading to neuronal death. PD is …
Urolithin A in health and diseases: Prospects for Parkinson's disease management
O Wojciechowska, M Kujawska - Antioxidants, 2023 - mdpi.com
Parkinson's disease (PD) is a chronic and progressive neurodegenerative disorder
characterized by a complex pathophysiology and a range of symptoms. The prevalence …
characterized by a complex pathophysiology and a range of symptoms. The prevalence …
Common genetic risk for Parkinson's disease and dysfunction of the endo-lysosomal system
N Bhore, EC Bogacki… - … of the Royal …, 2024 - royalsocietypublishing.org
Parkinson's disease is a progressive neurological disorder, characterized by prominent
movement dysfunction. The past two decades have seen a rapid expansion of our …
movement dysfunction. The past two decades have seen a rapid expansion of our …