Susceptibility to type 1 diabetes is associated strongly with human leucocyte antigen (HLA)
genes, implicating T cells in disease pathogenesis. In humans, CD8 T cells predominantly …

Studies over the last 20 years have examined the possible involvement of cytokines in the
pathogenesis of type 1 diabetes (T1DM) through a variety of approaches:(a) correlation …

The underlying cause of type 1 diabetes, loss of β-cell function, has become the therapeutic
target for a number of interventions in patients with type 1 diabetes. Even though insulin …

Background: Asthma is generally regarded as a disease with strong TH2-type cytokine
expression, whereas in autoimmune disorders, such as coeliac disease (CD), insulin …

Psychological stress is a public health issue even in children and has been associated with
a number of immunological diseases. The aim of this study was to examine the relationship …

Background Obesity and type 2 diabetes mellitus are characterized by insulin resistance
and 'low‐grade inflammation'; however, the pathophysiological link is poorly understood. To …

We investigated the expression of Th1-and Th2-associated chemokine receptors on
peripheral blood lymphocytes at diagnosis and in the first phase of type 1 diabetes …

Abstract Aims/hypothesis. Interleukin (IL)-18 is a cytokine primarily produced by
macrophages and capable of inducing T lymphocyte synthesis of interferon (IFN)-γ. An up …

The identification of sensitive assay formats capable of distinguishing islet autoreactive T
cells directly ex vivo in blood is a major goal in type 1 diabetes research. Recently, much …

Type 1 diabetes mellitus (T1DM) results from the immune cell-mediated destruction of
functional pancreatic β-cells. In the presymptomatic period, T1DM is characterized by the …