The emergence, implementation, and future growth of pharmacogenomics in psychiatry: a narrative review
Psychotropic medication efficacy and tolerability are critical treatment issues faced by
individuals with psychiatric disorders and their healthcare providers. For some people, it can …
individuals with psychiatric disorders and their healthcare providers. For some people, it can …
New insights from the last decade of research in psychiatric genetics: discoveries, challenges and clinical implications
Psychiatric genetics has made substantial progress in the last decade, providing new
insights into the genetic etiology of psychiatric disorders, and paving the way for precision …
insights into the genetic etiology of psychiatric disorders, and paving the way for precision …
Polygenic scores in psychiatry: on the road from discovery to implementation
The hypothesis that multiple genetic variants contribute to psychiatric disorders was first
proposed for schizophrenia in the 1960s, based on epidemiological data (1). This polygenic …
proposed for schizophrenia in the 1960s, based on epidemiological data (1). This polygenic …
Barriers to genetic testing in clinical psychiatry and ways to overcome them: from clinicians' attitudes to sociocultural differences between patients across the globe
J Pinzón-Espinosa, M van der Horst, J Zinkstok… - Translational …, 2022 - nature.com
Genetic testing has evolved rapidly over recent years and new developments have the
potential to provide insights that could improve the ability to diagnose, treat, and prevent …
potential to provide insights that could improve the ability to diagnose, treat, and prevent …
Pharmacogenomic scores in psychiatry: systematic review of current evidence
NT Sharew, SR Clark, KO Schubert… - Translational Psychiatry, 2024 - nature.com
In the past two decades, significant progress has been made in the development of
polygenic scores (PGSs). One specific application of PGSs is the development and potential …
polygenic scores (PGSs). One specific application of PGSs is the development and potential …
Metabolic activity of CYP2C19 and CYP2D6 on antidepressant response from 13 clinical studies using genotype imputation: a meta-analysis
Cytochrome P450 enzymes including CYP2C19 and CYP2D6 are important for
antidepressant metabolism and polymorphisms of these genes have been determined to …
antidepressant metabolism and polymorphisms of these genes have been determined to …
EraSOR: a software tool to eliminate inflation caused by sample overlap in polygenic score analyses
Background Polygenic risk score (PRS) analyses are now routinely applied across
biomedical research. However, as PRS studies grow in size, there is an increased risk of …
biomedical research. However, as PRS studies grow in size, there is an increased risk of …
The effects of CYP2C19 genotype on proxies of SSRI antidepressant response in the UK biobank
Selective serotonin reuptake inhibitors (SSRIs) are the most commonly used
psychopharmaceutical treatment for major depressive disorder (MDD), but individual …
psychopharmaceutical treatment for major depressive disorder (MDD), but individual …
Exome-wide association study of treatment-resistant depression suggests novel treatment targets
SB Shah, TN Peddada, C Song, M Mensah, H Sung… - Scientific Reports, 2023 - nature.com
Abstract Treatment-resistant depression (TRD) is a severe form of major depressive disorder
(MDD) with substantial public health impact and poor treatment outcome. Treatment …
(MDD) with substantial public health impact and poor treatment outcome. Treatment …
Polygenic risk scores of lithium response and treatment resistance in major depressive disorder
Abstract Treatment response and resistance in major depressive disorder (MDD) are
suggested to be heritable. Due to significant challenges in defining treatment-related …
suggested to be heritable. Due to significant challenges in defining treatment-related …