Filopodia are dynamic cell surface protrusions used for cell motility, pathogen infection, and
tissue development. The molecular mechanisms determining how and where filopodia grow …

Cells use the actin cytoskeleton for many of their functions, including their division,
adhesion, mechanosensing, endo-and phagocytosis, migration, and invasion. Actin bundles …

The mechanoreceptive sensory hair cells in the inner ear are selectively vulnerable to
numerous genetic and environmental insults. In mammals, hair cells lack regenerative …

Usher syndrome (USH) is an autosomal recessive syndromic ciliopathy characterized by
sensorineural hearing loss, retinitis pigmentosa and, sometimes, vestibular dysfunction …

Sensory neurons use specialized apical processes to perceive external stimuli and monitor
internal body conditions. The apical apparatus can include cilia, microvilli, or both, and is …

Sensory hair cells are specialized secondary sensory cells that mediate our senses of
hearing, balance, linear acceleration, and angular acceleration (head rotation). In addition …

The transduction compartment of inner ear hair cells, the hair bundle, is composed of
stereocilia rows of graded height, a property essential for sensory function that remains …

Filopodia, microvilli and stereocilia represent an important group of plasma membrane
protrusions. These specialized projections are supported by parallel bundles of actin …

Hearing loss is the most common form of sensory impairment in humans, affecting 5.3%
worldwide population. Although approximately 1 in 500 children are born with impaired …

Aging, disease, and trauma can lead to loss of vestibular hair cells and permanent vestibular
dysfunction. Previous work showed that, following acute destruction of∼ 95% of vestibular …