Targeting cancer metabolism in the era of precision oncology
One hundred years have passed since Warburg discovered alterations in cancer
metabolism, more than 70 years since Sidney Farber introduced anti-folates that …
metabolism, more than 70 years since Sidney Farber introduced anti-folates that …
Role of LDH in tumor glycolysis: regulation of LDHA by small molecules for cancer therapeutics
D Sharma, M Singh, R Rani - Seminars in cancer biology, 2022 - Elsevier
Lactate dehydrogenase (LDH) is one of the crucial enzymes in aerobic glycolysis, catalyzing
the last step of glycolysis, ie. the conversion of pyruvate to lactate. Most cancer cells are …
the last step of glycolysis, ie. the conversion of pyruvate to lactate. Most cancer cells are …
The multiple roles of LDH in cancer
G Claps, S Faouzi, V Quidville, F Chehade… - Nature Reviews …, 2022 - nature.com
High serum lactate dehydrogenase (LDH) levels are typically associated with a poor
prognosis in many cancer types. Even the most effective drugs, which have radically …
prognosis in many cancer types. Even the most effective drugs, which have radically …
Interpretable bilinear attention network with domain adaptation improves drug–target prediction
Predicting drug–target interaction is key for drug discovery. Recent deep learning-based
methods show promising performance, but two challenges remain: how to explicitly model …
methods show promising performance, but two challenges remain: how to explicitly model …
Lactate in the tumor microenvironment: an essential molecule in cancer progression and treatment
R Pérez-Tomás, I Pérez-Guillén - Cancers, 2020 - mdpi.com
Simple Summary The role of lactate in cancer described by Otto Warburg in 1927 states that
cancer cells uptake high amount of glucose with a marked increase in lactate production …
cancer cells uptake high amount of glucose with a marked increase in lactate production …
Protein-metabolite interactomics of carbohydrate metabolism reveal regulation of lactate dehydrogenase
Metabolic networks are interconnected and influence diverse cellular processes. The protein-
metabolite interactions that mediate these networks are frequently low affinity and …
metabolite interactions that mediate these networks are frequently low affinity and …
Lactate: a metabolic driver in the tumour landscape
The presence of lactate in human tumours has been long neglected, confined to the role of a
waste product derived from glycolysis and as a biomarker of malignancy. More recently …
waste product derived from glycolysis and as a biomarker of malignancy. More recently …
[HTML][HTML] HIFs, angiogenesis, and metabolism: elusive enemies in breast cancer
EC de Heer, M Jalving, AL Harris - The Journal of clinical …, 2020 - Am Soc Clin Investig
Hypoxia-inducible factors (HIFs) and the HIF-dependent cancer hallmarks angiogenesis and
metabolic rewiring are well-established drivers of breast cancer aggressiveness, therapy …
metabolic rewiring are well-established drivers of breast cancer aggressiveness, therapy …
Targeting metabolism to regulate immune responses in autoimmunity and cancer
Metabolic programming is emerging as a critical mechanism to alter immune cell activation,
differentiation and function. Targeting metabolism does not completely suppress or activate …
differentiation and function. Targeting metabolism does not completely suppress or activate …
Lactate dehydrogenase inhibition synergizes with IL-21 to promote CD8+ T cell stemness and antitumor immunity
D Hermans, S Gautam… - Proceedings of the …, 2020 - National Acad Sciences
Interleukin (IL)-2 and IL-21 dichotomously shape CD8+ T cell differentiation. IL-2 drives
terminal differentiation, generating cells that are poorly effective against tumors, whereas IL …
terminal differentiation, generating cells that are poorly effective against tumors, whereas IL …