Cell transplantation holds immense potential for reversing diseases that are currently
incurable and for regenerating tissues. However, poor cell survival, cell aggregation and …

The epidermal growth factor receptor (EGFR) belongs to the ErbB family of receptor tyrosine
kinases (RTK). These trans-membrane proteins are activated following binding with peptide …

Breast cancer progression involves multiple genetic events, which can activate dominant-
acting oncogenes and disrupt the function of specific tumor suppressor genes. This article …

Animal models are powerful tools to analyze the mechanism of the induction of human
breast cancer. Here we report a detailed analysis of mammary tumor progression in one …

Transforming growth factor-β (TGFβ) signalling regulates cancer through mechanisms that
function either within the tumour cell itself or through host–tumour cell interactions. Studies …

The epidermal growth factor receptor (EGFR) regulates key processes of cell biology,
including proliferation, survival, and differentiation during development, tissue homeostasis …

TGF-β signaling regulates tumorigenesis and in human cancer its signaling pathways are
often modified during tumor progression. Prior to initiation and early during progression TGF …

Progress in identifying and understanding the molecular and cellular causes of cancer has
led to the discovery of anomalies that characterize cancer cells and that represent targets for …

Targeted mice lacking functional EGF or amphiregulin (AR) were derived and bred to the
TGFα-knockout to generate mice lacking various combinations of the three ligands. In …

NIH sponsored a meeting of medical and veterinary pathologists with mammary gland
expertise in Annapolis in March 1999. Rapid development of mouse mammary models has …