[HTML][HTML] Biodegradable m-PEG/PCL core-shell micelles: preparation and characterization as a sustained release formulation for curcumin
Purpose: Among the potent anticancer agents, curcumin is known as a very efficacious
against many different types of cancer cells, but its clinical applications has been limited …
against many different types of cancer cells, but its clinical applications has been limited …
Codelivery of curcumin and doxorubicin by MPEG-PCL results in improved efficacy of systemically administered chemotherapy in mice with lung cancer
BL Wang, Y Shen, Q Zhang, Y Li, M Luo… - International Journal …, 2013 - Taylor & Francis
Systemic administration of chemotherapy for cancer often has toxic side effects, limiting the
doses that can be used in its treatment. In this study, we developed methoxy poly (ethylene …
doses that can be used in its treatment. In this study, we developed methoxy poly (ethylene …
Design and synthesis of novel 1, 3, 4-oxadiazole and 1, 2, 4-triazole derivatives as cyclooxygenase-2 inhibitors with anti-inflammatory and antioxidant activity in LPS …
MMS Hamoud, NA Osman, S Rezq… - Bioorganic …, 2022 - Elsevier
In an attempt to obtain new candidates with potential anti-inflammatory activity, two series of
1, 3, 4-oxadiazole based derivatives (8a–g) and 1, 2, 4-triazole based derivatives (10a, b …
1, 3, 4-oxadiazole based derivatives (8a–g) and 1, 2, 4-triazole based derivatives (10a, b …
[HTML][HTML] Study of the composition of polycaprolactone/poly (ethylene glycol)/polycaprolactone copolymer and drug-to-polymer ratio on drug loading efficiency of …
H Danafar - Jundishapur Journal of Natural Pharmaceutical …, 2017 - brieflands.com
Background: Natural products derived from plants play a significant function in healthcare in
many cultures, both ancient and modern. curcumin (CUR) is a chemical constituent of …
many cultures, both ancient and modern. curcumin (CUR) is a chemical constituent of …
Design and synthesis of novel chloropyridazine hybrids as promising anticancer agents acting by apoptosis induction and PARP-1 inhibition through a molecular …
NA Abdelrahman, AA Al-Karmalawy… - RSC Medicinal …, 2024 - pubs.rsc.org
Guided by the molecular hybridization principle, a novel series of 4-
chloropyridazinoxyphenyl conjugates (3a–h, 4a–e, and 5) was designed and synthesized as …
chloropyridazinoxyphenyl conjugates (3a–h, 4a–e, and 5) was designed and synthesized as …
Recent advances in anti-inflammatory potential of pyridazinone derivatives
M Saini, DK Mehta, R Das… - Mini Reviews in Medicinal …, 2016 - ingentaconnect.com
Pyridazinone and its derivatives have various ranges of biological and pharmacological
activities including anti-inflammatory, antifeedant, anticonvulsant, antidiabetic, herbicidal …
activities including anti-inflammatory, antifeedant, anticonvulsant, antidiabetic, herbicidal …
[HTML][HTML] Synthesis of new nicotinic acid derivatives and their evaluation as analgesic and anti-inflammatory agents
A series of 2-substituted phenyl derivatives of nicotinic acid 4a–l were synthesized and
evaluated for their analgesic and anti-inflammatory activities. Compounds including 2 …
evaluated for their analgesic and anti-inflammatory activities. Compounds including 2 …
Towards discovery of novel scaffold with potent antiangiogenic activity; design, synthesis of pyridazine based compounds, impact of hinge interaction, and …
MY Jaballah, RAT Serya, N Saad… - Journal of Enzyme …, 2019 - Taylor & Francis
Pyridazine scaffolds are considered privileged structures pertaining to its novelty, chemical
stability, and synthetic feasibility. In our quest towards the development of novel scaffolds for …
stability, and synthetic feasibility. In our quest towards the development of novel scaffolds for …
Synthesis and biological evaluation of new nicotinic acid derivatives as potential anti-inflammatory agents with enhanced gastric safety profile
Two innovative series derived from nicotinic acid scaffold were synthesized and evaluated
for their anti-inflammatory activity. Ibuprofen, celecoxib and indomethacin were used as …
for their anti-inflammatory activity. Ibuprofen, celecoxib and indomethacin were used as …
Efficient 1, 3, 4-Thiadiazole-4, 5-dihydropyridazin-3 (2H)-ones as Antimicrobial Agents
YAM El-Badry, MS Sallam… - Chemical and …, 2018 - jstage.jst.go.jp
A set of novel series of 1, 3, 4-thiadiazolyl-sulfanyl-4, 5-dihydropyridazin-3 (2H)-ones with
anticipated antimicrobial activity has been synthesized. The synthetic protocol of the …
anticipated antimicrobial activity has been synthesized. The synthetic protocol of the …