Repeat expansion mutations cause at least 22 inherited neurological diseases. The
complexity of repeat disease genetics and pathobiology has revealed unexpected shared …

Current epigenomics approaches have facilitated the genome-wide identification of
regulatory elements based on chromatin features and transcriptional regulator binding and …

Estrogen receptor α (ERα) upregulation causes abnormal cell proliferation in about two
thirds of breast cancers, yet understanding of the underlying mechanisms remains …

During the haploid phase of mammalian spermatogenesis, nucleosomal chromatin is
ultimately repackaged by small, highly basic protamines to generate an extremely compact …

Intragenic 5‐methylcytosine and CTCF mediate opposing effects on pre‐mRNA splicing:
CTCF promotes inclusion of weak upstream exons through RNA polymerase II pausing …

Simple Summary Over the past few decades, despite advances in colon cancer surgery, the
pro-gnosis of late colon cancer patients with liver metastasis remains poor. Currently, its …

At least 25 inherited disorders in humans result from microsatellite repeat expansion.
Dramatic variation in repeat instability occurs at different disease loci and between different …

Epigenetic silencing of tumor suppressor gene promoters has become a more frequent
phenomenon in cancer than previously anticipated. In this study we addressed the …

Simple Summary Epigenetics studies the alteration of gene expression without changing
DNA sequence and very often, epigenetic dysregulation causes cancer. Alternative splicing …

Aberrant alternative splicing and epigenetic changes are both associated with various
cancers, but epigenetic regulation of alternative splicing in cancer is largely unknown. Here …