The macrophage: a key player in the pathophysiology of peripheral neuropathies

Z Msheik, M El Massry, A Rovini, F Billet… - Journal of …, 2022 - Springer
Macrophages are present in all mammalian tissues and coexist with various cell types in
order to respond to different environmental cues. However, the role of these cells has been …

Emerging therapies for Charcot-Marie-Tooth inherited neuropathies

M Stavrou, I Sargiannidou, E Georgiou… - International Journal of …, 2021 - mdpi.com
Inherited neuropathies known as Charcot-Marie-Tooth (CMT) disease are genetically
heterogeneous disorders affecting the peripheral nerves, causing significant and slowly …

Curcumin–cyclodextrin/cellulose nanocrystals improve the phenotype of Charcot-Marie-Tooth-1A transgenic rats through the reduction of oxidative stress

M Caillaud, Z Msheik, GMA Ndong-Ntoutoume… - Free Radical Biology …, 2020 - Elsevier
The most prevalent form of Charcot-Marie-Tooth disease (CMT type 1A) is characterized by
duplication of the PMP22 gene, peripheral dysmyelination and decreased nerve conduction …

The current state of Charcot–Marie–Tooth disease treatment

Y Okamoto, H Takashima - Genes, 2023 - mdpi.com
Charcot–Marie–Tooth disease (CMT) and associated neuropathies are the most
predominant genetically transmitted neuromuscular conditions; however, effective …

Melatonin rescues glucocorticoid-induced inhibition of osteoblast differentiation in MC3T3-E1 cells via the PI3K/AKT and BMP/Smad signalling pathways

R Zhao, L Tao, S Qiu, L Shen, Y Tian, Z Gong, ZB Tao… - Life sciences, 2020 - Elsevier
Aims High-dose glucocorticoid (GC) administration causes osteoporosis. Many previous
studies from our group and other groups have shown that melatonin participates in the …

Hypothermia plus melatonin in asphyctic newborns: a randomized-controlled pilot study

A Jerez-Calero, MT Salvatierra-Cuenca… - Pediatric Critical Care …, 2020 - journals.lww.com
Objectives: To investigate the effect of adding melatonin to hypothermia treatment on
neurodevelopmental outcomes in asphyctic newborns. Design: Pilot multicenter …

Melatonin as a powerful antioxidant

A Chrustek, D Olszewska-Słonina - Acta Pharmaceutica, 2021 - hrcak.srce.hr
Sažetak Melatonin is a hormone that has many body functions and, for several decades, its
antioxidant potential has been increasingly talked about. There is a relationship between …

Neuroinflammation in the pathogenesis of axonal Charcot-Marie-Tooth disease caused by lack of GDAP1

S Fernandez-Lizarbe, A Civera-Tregon… - Experimental …, 2019 - Elsevier
Mutations in the GDAP1 mitochondrial outer membrane gene cause Charcot-Marie-Tooth
(CMT) neuropathy. Reduction or absence of GDAP1 has been associated with abnormal …

In vitro toxicity of dimethyl phthalate to human erythrocytes: From the aspects of antioxidant and immune functions

S Li, Z Chi, W Li - Environmental pollution, 2019 - Elsevier
In the study, the effects of dimethyl phthalate (DMP) on the antioxidant defense capacity and
immune functions of human erythrocytes were experimentally explored. DMP affected the …

Calcium deregulation and mitochondrial bioenergetics in GDAP1-related CMT disease

P González-Sánchez, J Satrústegui, F Palau… - International journal of …, 2019 - mdpi.com
The pathology of Charcot-Marie-Tooth (CMT), a disease arising from mutations in different
genes, has been associated with an impairment of mitochondrial dynamics and axonal …