Synthetic advances in the indane natural product scaffolds as drug candidates: a review

N Ahmed - Studies in Natural Products Chemistry, 2016 - Elsevier
Widespread outbreak of numerous infectious diseases and metabolic disorders across the
globe has created awareness among the chemists for novel design and synthesis of natural …

Transition‐Metal‐Free Synthesis of 1‐Indanone Skeleton: A Brief Update

S Das - ChemistrySelect, 2021 - Wiley Online Library
Transition‐metal‐free carbon‐carbon bond forming reactions have drawn great interest
because they are operationally simple, cost‐effective and environmentally benign. However …

Pd(II)-Catalyzed Direct ortho-C–H Acylation of Aromatic Ketones by Oxidative Decarboxylation of α-Oxocarboxylic Acids

PY Lee, P Liang, WY Yu - Organic letters, 2017 - ACS Publications
A Pd-catalyzed decarboxylative acylation of aromatic ketones with α-oxocarboxylic acids
was developed, and 1, 2-diacylbenzenes were formed in up to 90% yield with excellent …

Developments toward the synthesis and application of 3-hydroxyindanones

T Chanda, MS Singh - Organic & Biomolecular Chemistry, 2016 - pubs.rsc.org
3-Hydroxyindanone is an important scaffold in many natural products, biologically active
compounds, and functional materials. This review provides a comprehensive overview of the …

Metal-and hydride-free pentannulative reductive aldol reaction

B Satpathi, L Dutta, SSV Ramasastry - Organic letters, 2018 - ACS Publications
Traditionally, the reductive aldol reaction is a metal-catalyzed and hydride-promoted
coupling between enones and aldehydes. We present a phosphine-mediated …

Natural amino acid salt catalyzed aldol reactions of isatins with ketones: Highly enantioselective construction of 3-alkyl-3-hydroxyindolin-2-ones

G Chen, Y Ju, T Yang, Z Li, W Ang, Z Sang, J Liu… - Tetrahedron …, 2015 - Elsevier
The asymmetric synthesis of 3-alkyl-3-hydroxyindolin-2-ones via direct aldol reaction of
isatin with ketones catalyzed by natural amino acid salts is described, in which the …

Organocatalysis in the Synthesis of Natural Products: Recent Developments in Aldol and Mannich Reactions, and 1, 4-Conjugated Additions

E Dibello, D Gamenara, G Seoane - Current Organocatalysis, 2015 - ingentaconnect.com
The use of organocatalysis has simplified and increased the potential of synthetic
approaches to natural products. Different aspects, regarding applications and even …

Phosphine-and water-promoted pentannulative aldol reaction

B Satpathi, L Dutta, SSV Ramasastry - Organic & Biomolecular …, 2019 - pubs.rsc.org
Herein, an efficient metal-free intramolecular aldol reaction for the synthesis of an unusual
class of cyclopentanoids is described. The reaction of α-substituted dienones tethered with …

Toward Second‐Generation Cardiomyogenic and Anti‐cardiofibrotic 1, 4‐Dihydropyridine‐Class TGFβ Inhibitors

D Längle, TR Werner, F Wesseler, E Reckzeh… - …, 2019 - Wiley Online Library
Innovative therapeutic modalities for pharmacological intervention of transforming growth
factor β (TGFβ)‐dependent diseases are of great value. b‐Annelated 1, 4‐dihydropyridines …

Divergent Michael/Aldol cascades under semi-aqueous conditions: synthesis of cyclopenta-and cycloheptannulated (hetero) arenes

JP Maurya, SSV Ramasastry - The Journal of Organic Chemistry, 2020 - ACS Publications
The synthesis of 3-acetoxyindanones and (hetero) arene-fused dihydrotropones was
achieved via divergent annulation cascades. Under mild aqueous and basic conditions, α …