Glaucoma is a neurodegenerative disease characterized by the progressive loss of retinal
ganglion cells (RGC s). Elevated intraocular pressure (IOP) is a primary risk factor for the …

Highlights•P2X7 has multiple actions depending on the level of exposure to extracellular
ATP.•Major retinal diseases are attributed to excessive activation of P2X7 receptors.•The …

Alzheimer's disease is characterized by the aberrant deposition of protein in the brain and is
the leading cause of dementia worldwide. Increasingly, there have been reports of the …

Glaucoma is a disease associated with the loss of retinal ganglion cells (RGCs), and
remains one of the primary causes of blindness worldwide. Major research efforts are …

In addition to well characterized motor symptoms, visual disturbances are increasingly
recognized as an early manifestation in Parkinson's disease (PD). A better understanding of …

Aging and elevated intraocular pressure (IOP) are two major risk factors for glaucomatous
optic neuropathy; a condition characterized by the selective, progressive injury, and …

Glaucoma is an optic neuropathy in which the degeneration of retinal ganglion cells (RGCs)
results in irreversible vison loss. Therefore, neuroprotection of RGCs from glaucomatous …

Abnormal alpha-synuclein (α-SYN) protein deposition has long been recognized as one of
the pathological hallmarks of Parkinson's disease's (PD). This study considers the potential …

Glaucoma is a neurodegenerative disease characterised by progressive damage to the
retinal ganglion cells (RGCs), the output neurons of the retina. RGCs are a heterogenous …

Purpose: To test the hypothesis that the capacity for retinal ganglion cells to functionally
recover from chronic IOP elevation is dependent on the duration of IOP elevation. Methods …