All implanted biomaterials are targets of the host's immune system. While the host
inflammatory response was once considered a detrimental force to be blunted or avoided, in …

Acute inflammation is essential for initiating and coordinating the body's response to injuries
and infections. However, in acute inflammatory diseases, inflammation is not resolved but …

The development of therapeutic approaches for the induction of robust, long-lasting and
antigen-specific immune tolerance remains an important unmet clinical need for the …

SARS-CoV-2 has caused up to 127 million cases of COVID-19. Approximately 5% of COVID-
19 patients develop severe illness, and approximately 40% of those with severe illness …

Nanoparticle-based drug delivery systems have been synthesized from a wide array of
materials. The therapeutic success of these platforms hinges upon their ability to favorably …

Polymeric particles have recently been used to modulate the behavior of immune cells in the
treatment of various inflammatory conditions. However, there is little understanding of how …

Innate immunity is the first line of defense against invading pathogens. Innate immune cells
can recognize invading pathogens through recognizing pathogen-associated molecular …

Neutrophilia and the production of neutrophil extracellular traps (NETs) are two of many
measures of increased inflammation in severe COVID-19 that also accompany its …

Inflammation is a key homeostatic process involved in the body's response to a multitude of
disease states including infection, autoimmune disorders, cancer, and other chronic …

Sepsis is a life-threatening organ dysfunction resulting from dysregulated host responses to
infection. Macrophages play significant roles in host against pathogens and the …