Centrioles are conserved microtubule-based organelles that form the core of the centrosome
and act as templates for the formation of cilia and flagella. Centrioles have important roles in …

The centriole is an ancient microtubule-based organelle with a conserved nine-fold
symmetry. Centrioles form the core of centrosomes, which organize the interphase …

HNRNPU encodes the heterogeneous nuclear ribonucleoprotein U, which participates in
RNA splicing and chromatin organization. Microdeletions in the 1q44 locus encompassing …

Microcephaly or reduced head circumference results from a multitude of abnormal
developmental processes affecting brain growth and/or leading to brain atrophy. Autosomal …

Centrioles are eukaryotic subcellular structures that produce and regulate massive
cytoskeleton superstructures. They form centrosomes and cilia, regulate new centriole …

Multiciliated cells (MCC) project dozens to hundreds of motile cilia from the cell surface to
generate fluid flow across epithelial surfaces or turbulence to promote the transport of …

Epidemiological evidence from the current outbreak of Zika virus (ZIKV) and recent studies
in animal models indicate a strong causal link between ZIKV and microcephaly. ZIKV …

In this study, we take advantage of human induced pluripotent stem (iPS) cell-derived neural
stem cells and brain organoids to study the role of p53 during human brain development …

While it is well appreciated that loss of the p53 tumor suppressor protein promotes cancer,
growing evidence indicates that increased p53 activity underlies the developmental defects …

The centrosome, consisting of centrioles and the associated pericentriolar material, is the
main microtubule-organizing centre (MTOC) in animal cells. During most of interphase, the …