Cardiac arrhythmias are among the leading causes of mortality. They often arise from
alterations in the electrophysiological properties of cardiac cells and their underlying ionic …

Optical mapping is an imaging technique that is extensively used in cardiovascular
research, wherein parameter-sensitive fluorescent indicators are used to study the …

The analysis of beating rate provides information on the modulatory action of the autonomic
nervous system on the heart, which mediates adjustments of cardiac function to meet …

Diabetes and other metabolic conditions characterized by elevated blood glucose constitute
important risk factors for cardiovascular disease. Hyperglycemia targets myocardial cells …

Notch receptor signaling is active during cardiac development and silenced in myocytes
after birth. Conversely, outward K+ Kv currents progressively appear in postnatal myocytes …

Cardiovascular diseases are major causes of death in the western world and this incidence
increases in the elderly population. With aging, there are physiologic changes to the cardiac …

Heart rate variability (HRV) is a measure of variation in time interval between heartbeats and
reflects the influence of autonomic nervous system and circulating/locally released factors …

The world population is aging, and by 2017, there will be more people over the age of 65
than under age 5, and by 2050, two billion of the estimated nine billion people on Earth will …

Voltage-gated sodium channels (VGSCs) are macromolecular assemblies composed of a
number of proteins regulating channel conductance and properties. VGSCs generate Na+ …

Numerous changes occur in the old myocardium which finally cause lower cardiac output
and, therefore, circulatory dysfunction. In order to identify an age-related gene expression …