Biological and pharmacological roles of m6A modifications in cancer drug resistance

Z Liu, H Zou, Q Dang, H Xu, L Liu, Y Zhang, J Lv, H Li… - Molecular Cancer, 2022 - Springer
Cancer drug resistance represents the main obstacle in cancer treatment. Drug-resistant
cancers exhibit complex molecular mechanisms to hit back therapy under pharmacological …

N6-methyladenosine reader YTHDF family in biological processes: structures, roles, and mechanisms

L Chen, Y Gao, S Xu, J Yuan, M Wang, T Li… - Frontiers in …, 2023 - frontiersin.org
As the most abundant and conserved internal modification in eukaryote RNAs, N6-
methyladenosine (m6A) is involved in a wide range of physiological and pathological …

The lncRNA epigenetics: the significance of m6A and m5C lncRNA modifications in cancer

VY Cusenza, A Tameni, A Neri, R Frazzi - Frontiers in oncology, 2023 - frontiersin.org
Most of our transcribed RNAs are represented by non-coding sequences. Long non-coding
RNAs (lncRNAs) are transcripts with no or very limited protein coding ability and a length> …

Alternative splicing and related RNA binding proteins in human health and disease

Y Tao, Q Zhang, H Wang, X Yang, H Mu - Signal Transduction and …, 2024 - nature.com
Alternative splicing (AS) serves as a pivotal mechanism in transcriptional regulation,
engendering transcript diversity, and modifications in protein structure and functionality …

RNA modification in cardiovascular disease: implications for therapeutic interventions

C Wang, X Hou, Q Guan, H Zhou, L Zhou… - … and Targeted Therapy, 2023 - nature.com
Cardiovascular disease (CVD) is the leading cause of death in the world, with a high
incidence and a youth-oriented tendency. RNA modification is ubiquitous and indispensable …

Novel insights into mutual regulation between N6-methyladenosine modification and LncRNAs in tumors

N Zhang, Y Sun, Z Mei, Z He, S Gu - Cancer Cell International, 2023 - Springer
Abstract N6-methyladenosine (m6A), one of the most common RNA methylation
modifications, has emerged in recent years as a new layer of the regulatory mechanism …

HOTAIR: A key regulator of the Wnt/β-catenin signaling cascade in cancer progression and treatment

MA Hakami, A Hazazi, O Abdulaziz… - … -Research and Practice, 2023 - Elsevier
The long non-coding RNA (lncRNA) HOTAIR occupies a central position in the complex
domain of cancer biology, particularly concerning its intricate interplay with the Wnt/β …

Genetic and pharmacological inhibition of METTL3 alleviates renal fibrosis by reducing EVL m6A modification through an IGF2BP2‐dependent mechanism

WJ Ni, H Zhou, H Lu, NN Ma, BB Hou… - Clinical and …, 2023 - Wiley Online Library
Abstract Background N6‐methyladenosine (m6A) is of great importance in renal physiology
and disease progression, but its function and mechanism in renal fibrosis remain to be …

The strict regulation of HIF-1α by non-coding RNAs: new insight towards proliferation, metastasis, and therapeutic resistance strategies

SF Jawad, FMA Altalbawy, RM Hussein… - Cancer and Metastasis …, 2024 - Springer
The hypoxic environment is prominently witnessed in most solid tumors and is associated
with the promotion of cell proliferation, epithelial-mesenchymal transition (EMT) …

Natural antisense transcripts as versatile regulators of gene expression

A Werner, A Kanhere, C Wahlestedt… - Nature Reviews …, 2024 - nature.com
Long non-coding RNAs (lncRNAs) are emerging as a major class of gene products that
have central roles in cell and developmental biology. Natural antisense transcripts (NATs) …